P9389

Poly(deoxyguanylic-deoxycytidylic) acid sodium salt

Name: Poly(deoxyguanylic-deoxycytidylic) acid sodium salt
Brand: SIGMA

double stranded, alternating copolymer

Synonym(s):

Poly(dG-dC) • Poly(dG-dC)

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About This Item

CAS Number:

90385-88-9

UNSPSC Code:

41106305

NACRES:

NA.51

MDL number:

MFCD00131968

Product Name

Poly(deoxyguanylic-deoxycytidylic) acid sodium salt, double stranded, alternating copolymer

biological source

synthetic (organic)

form

powder or solid

storage temp.

−20°C

Quality Level

200

Application

Poly(deoxyguanylic-deoxycytidylic) acid (Poly(dG-dC) • Poly(dG-dC)) is an alternating copolymer, self-complementary, double-stranded DNA model for conformational studies of DNA structure dynamics and drug interaction.

Poly(deoxyguanylic-deoxycytidylic) acid sodium salt has been used:

in electrophoretic mobility shift assay of transcription factor IIIB complex
as synthetic copolymers for circular dichroism (CD) spectroscopy studies
as a positive control in liquid scintillation counting

General description

Poly(deoxyguanylic-deoxycytidylic) acid (poly(dG-dC)) undergoes salt dependent conformational transition. Under high-salt, it exists as a left-handed double helix and at low-salt it displays B-DNA conformation. However on immobilization, poly(dG-dC) takes up A DNA form.

Other Notes

Alternating copolymer; self-complementary, form double-stranded complex

One unit will yield an A₂₆₀ of 1.0 in 1.0 ml 20 mM sodium phosphate/100 mM NaCl, pH 7.0 (1cm light path).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

0000514631

0000437211

0000393456

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TFIIIB subunit locations on U6 gene promoter DNA mapped by site-specific protein-DNA photo-cross-linking

Kang JJ, et al.

Febs Letters, 590(10), 1488-1497 (2016)

Poly (dG)-poly (dC) DNA appears shorter than poly (dA)-poly (dT) and possibly adopts an A-related conformation on a mica surface under ambient conditions

Borovok N, et al.

Febs Letters, 581(30), 5843-5846 (2007)

Salt-dependent dynamic structure of poly (dG-dC) textperiodcentered poly (dG-dC)

Ramstein J and Leng M

Nature, 288(5789), 413-413 (1980)

Genomic DNA methylation decreases in response to moderate folate depletion in elderly women-

Rampersaud GC, et al.

American Journal of Clinical Nutrition, 72(4), 998-1003 (2000)

Role of excited states in low-energy electron (LEE) induced strand breaks in DNA model systems: influence of aqueous environment.

Anil Kumar et al.

Chemphyschem : a European journal of chemical physics and physical chemistry, 10(9-10), 1426-1430 (2009-03-25)

Low-energy electrons (LEEs) interact with a DNA model system to create a variety of excited states. In the gas phase, dissociative (sigma*) states are accessible by LEEs with energy <4 eV (see picture) and cause facile strand breaks through a

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