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S3699

Anti-SEL1L (N-terminal) antibody produced in rabbit

Name: Anti-SEL1L (N-terminal) antibody produced in rabbit
Brand: SIGMA

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-SEL1-like, Anti-Sel-1 suppressor of lin-12-like (C. elegans), Anti-Suppressor of lin-12-like

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About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IF, IP, WB

Citations:

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Properties

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~100 kDa

species reactivity

human

concentration

~1.0 mg/mL

technique(s)

immunoprecipitation (IP): 2-5 μg using lysate of human MCF-7 cells, indirect immunofluorescence: 2-4 μg/mL, western blot: 0.5-1.0 μg/mL using whole extracts of human MCF-7 cells

UniProt accession no.

Q9UBV2

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SEL1L(6400)

Description

General description

SEL1L (Sel-1-like) is a type I transmembrane glycoprotein, that is located in ER (endoplasmic reticulum). It is considered as a putative tumor suppressor gene. It is located on chromosome 14q.

SEL1L is highly expressed in the pancreas.

Application

Anti-SEL1L (N-terminal) antibody produced in rabbit has been used in

immunoblotting
immunoprecipitation
immunofluorescence

Biochem/physiol Actions

SEL1L (Sel-1-like) participates in the degradation pathway linked with endoplasmic reticulum (ER), malignant transformation and stem cells. It helps in the self regeneration of the neural stem cell. It controls cell fate developmental decision and homeostasis. It plays an important role in retaining homeostasis of endoplasmic reticulum throughout embryonic growth of vertebrate.

SEL1L is involved in cell growth and cancer progression.

Physical form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificates of Analysis (COA)

Lot/Batch Number

0000490143

0000443503

0000130597

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