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T7189

Tumor Necrosis Factor Soluble Receptor II (TNF sRII)/Fc Chimera human

Name: Tumor Necrosis Factor Soluble Receptor II (TNF sRII)/Fc Chimera human
Brand: SIGMA

>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

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About This Item

UNSPSC Code:

51111800

NACRES:

NA.32

MDL number:

MFCD02689206

Form:

lyophilized powder

Assay:

>95% (SDS-PAGE)

Biological source:

human

Recombinant:

expressed in NSO cells

Mol wt:

52.6 kDa

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Properties

biological source

human

Quality Level

200

recombinant

expressed in NSO cells

assay

>95% (SDS-PAGE)

form

lyophilized powder

potency

0.004-0.016 mg per mL ED₅₀

mol wt

52.6 kDa

packaging

pkg of 50 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

P20333

storage temp.

−20°C

Gene Information

human ... TNFRSF1B(7133)

Description

Application

Tumor Necrosis Factor Soluble Receptor II (TNF sRII)/Fc Chimera human can be used as a test compound for analyzing the interaction between tumor necrosis factor (TNF) and its two soluble receptors by using surface plasmon resonance (SPR) technique.

Biochem/physiol Actions

Tumor Necrosis Factor Soluble Receptor II (TNF sRII)/Fc Chimera human belongs to TNF family of receptors and mediates the metabolic effects of TNF-α. Tumor Necrosis Factor Soluble Receptor II blocks the TNF-α-induced apoptosis and hence regulates the TNF-α function. It also has a pivotal role in neutralizing the biological activities of both TNF-α and TNF-β.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline

Analysis Note

The biological activity is measured by its ability to neutralize the TNF-α mediated cytotoxicity in mouse L-929 cells in the presence of the metabolic inhibitor actinomycin D.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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