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Merck

47865-U

Nicotinamide (Niacinamide)

analytical standard

Synonym(s):

Nicotinamide, NAM, NIC, Niacinamide, Nicotinic acid amide, Pyridine-3-carboxylic acid amide, Vitamin B3, Vitamin PP

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About This Item

Empirical Formula (Hill Notation):
C6H6N2O
CAS Number:
98-92-0
Molecular Weight:
122.12
UNSPSC Code:
85151701
NACRES:
NA.24
PubChem Substance ID:
329757343
EC Number:
202-713-4
Beilstein/REAXYS Number:
383619
MDL number:
MFCD00006395

Product Name

Nicotinamide (Niacinamide), analytical standard

InChI

1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)

InChI key

DFPAKSUCGFBDDF-UHFFFAOYSA-N

SMILES string

NC(=O)c1cccnc1

grade

analytical standard

CofA

current certificate can be downloaded

feature

standard type water soluble vitamin

packaging

ampule of 1000 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

128-131 °C (lit.)

application(s)

clinical testing

format

neat

storage temp.

2-30°C

Gene Information

human ... PARP1(142), SIRT2(22933)

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Application

Nicotinamide (Niacinamide) may be used as a reference standard for the determination of the analyte in pharmaceutical formulations and biological fluids by chromatography, UV-visible spectrophotometry and multivariate analysis.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor

General description

Nicotinamide (Niacinamide), belonging to the class of water-soluble B vitamins, is typically produced from nicotinic acid (vitamin B3). It is found as a component of food products. It has been suggested for the treatment of pellagra, psoriasis, schizophrenia, and type I diabetes. It also exhibits anti-inflammatory activity.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

302.0 °F - closed cup

flash_point_c

150 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
LRAD9147
LRAD7518
LRAD5073
LRAC9819
LRAC6832

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Industrial application of green chromatography?I. Separation and analysis of niacinamide in skincare creams using pure water as the mobile phase
Yang Y, et al.
Talanta, 84(1), 169-174 (2011)
Development of a validated HPLC method for the determination of B-complex vitamins in pharmaceuticals and biological fluids after solid phase extraction
Chatzimichalakis PF, et al.
Journal of Separation Science, 27(14), 1181-1188 (2004)
Evaluation of analytical tools and multivariate methods for quantification of co-former crystals in ibuprofen-nicotinamide co-crystals
Soares FLF and Carneiro RL
Journal of Pharmaceutical and Biomedical Analysis, 89, 166-175 (2014)
Efrat Resnick et al.
Journal of the American Chemical Society, 141(22), 8951-8968 (2019-05-08)
Covalent probes can display unmatched potency, selectivity, and duration of action; however, their discovery is challenging. In principle, fragments that can irreversibly bind their target can overcome the low affinity that limits reversible fragment screening, but such electrophilic fragments were
Nicotinamide
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 14(4), 3145-3146 (2017)
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