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Merck

1335508

USP

Ibuprofen

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

p-Isobutylhydratropic acid, Benzeneacetic acid, α-Methyl-4-(isobutyl)phenylacetic acid, (±)-2-(4-Isobutylphenyl)propanoic acid

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About This Item

Empirical Formula (Hill Notation):
C13H18O2
CAS Number:
15687-27-1
Molecular Weight:
206.28
NACRES:
NA.24
PubChem Substance ID:
329750144
UNSPSC Code:
41116107
MDL number:
MFCD00010393

Product Name

Ibuprofen, United States Pharmacopeia (USP) Reference Standard

InChI

1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)

SMILES string

CC(C)Cc1ccc(cc1)C(C)C(O)=O

InChI key

HEFNNWSXXWATRW-UHFFFAOYSA-N

grade

pharmaceutical primary standard

API family

ibuprofen

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

Gene Information

human ... PTGS1(5742), PTGS2(5743)

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Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

Ibuprofen USP reference standard suitable for use in specified USP compendial tests and assays.

Also used to prepare standard preparation, standard and standard stock solution for performance tests, assay, identification, and impurity analysis according to the given below monographs of United States Pharmacopeia (USP):
  • Diphenhydramine Hydrochloride and Ibuprofen Capsules
  • Ibuprofen and Pseudoephedrine Hydrochloride Tablets

Biochem/physiol Actions

Cyclooxygenase (COX) inhibitor that has greater activity against COX-1 than against COX-2.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

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Exclamation mark
GHS07

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Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

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Ibuprofen and Pseudoephedrine Hydrochloride Tablets
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 2286-2286 (2013)
Diphenhydramine Hydrochloride and Ibuprofen Capsules
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 41(2), 1431-1431 (2020)
Yexuan Mao et al.
Talanta, 132, 894-901 (2014-12-06)
The fundamental studies for the binding events of protein and its partner are crucial in drug development. In this study, a novel technology named microscale thermophoresis (MST) was applied in the investigation of molecular interaction between an organic dye fluorescein
Sheena Derry et al.
The Cochrane database of systematic reviews, 10(10), CD007550-CD007550 (2013-10-24)
This review is an update of a previously published review in The Cochrane Database of Systematic Reviews Issue 3, 2009 on single dose oral dexibuprofen (S(+)-ibuprofen) for acute postoperative pain in adults.Dexibuprofen is a non-steroidal anti-inflammatory drug (NSAID) licensed for
Aleem Adatia et al.
The Journal of pharmacy and pharmacology, 64(5), 626-636 (2012-04-05)
We review the pharmacological properties and clinical evidence pertaining to the efficacy of ibuprofen as a first-line treatment in hip and knee osteoarthritis (OA). In the context of our previous paper's exploration of the aetiology and pathogenesis of OA as
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