90101
Ampliflu™ Red
suitable for fluorescence, ≥98.0% (HPLC)
Synonym(s):
10-Acetyl-3,7-dihydroxyphenoxazine
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About This Item
Empirical Formula (Hill Notation):
C14H11NO4
CAS Number:
Molecular Weight:
257.24
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352108
MDL number:
Quality Level
assay
≥98.0% (HPLC)
form
powder
mol wt
257.24 g/mol
concentration
90-100 % (w/w) (Ampliflu Red)
color
slightly brown-red, white to slightly brown
solubility
water: slightly soluble at 20 °C
fluorescence
λex 571 nm; λem 585 nm in DMSO
suitability
suitable for fluorescence
storage temp.
2-8°C
SMILES string
CC(=O)N1c2ccc(O)cc2Oc3cc(O)ccc13
InChI
1S/C14H11NO4/c1-8(16)15-11-4-2-9(17)6-13(11)19-14-7-10(18)3-5-12(14)15/h2-7,17-18H,1H3
InChI key
PKYCWFICOKSIHZ-UHFFFAOYSA-N
Application
Ampliflu™ Red has been used to study mitochondrial abnormalities and oxidative stress related to Parkinson’s Disease. Ampliflu™ Red assay was suitable as an alternative indicator assay for detecting the inhibition of hTPO (human thyroid peroxidase) activity. Phospholipase D, an essential cellular process ingredient, used Ampliflu™ Red (10-Acetyl-3,7-dihydroxyphenoxazine) to determine its activity.Ampliflu™ Red is used for the following applications:
- Quantification of inflammatory mediators
- Determination of free and esterified cholesterol contents
- Evaluation of compounds as substrates for GABA-AT compounds
Legal Information
Ampliflu is a trademark of Sigma-Aldrich Co. LLC
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Barae Jomaa et al.
ALTEX, 32(3), 191-200 (2015-03-31)
A simple and rapid luminometric assay for the detection of chemical inhibitors of human thyroid peroxidase (hTPO) activity was developed and validated with 10 model compounds. hTPO was derived from the human thyroid follicular cell line Nthy-ori 3-1 and its
Maria Luisa Di Paolo et al.
Journal of enzyme inhibition and medicinal chemistry, 34(1), 740-752 (2019-03-05)
Fourteen polyamine analogues, asymmetric or symmetric substituted spermine (1-9) or methoctramine (10-14) analogues, were evaluated as potential inhibitors or substrates of two enzymes of the polyamine catabolic pathway, spermine oxidase (SMOX) and acetylpolyamine oxidase (PAOX). Compound 2 turned out to
Anne H van der Spek et al.
Endocrine connections, 6(8), 731-740 (2017-11-05)
Innate immune cells have recently been identified as novel thyroid hormone (TH) target cells in which intracellular TH levels appear to play an important functional role. The possible involvement of TH receptor alpha (TRα), which is the predominant TR in