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T4143

Triamterene

≥99%

Synonym(s):

2,4,7-Triamino-6-phenylpteridine, 6-Phenyl-2,4,7-pteridinetriamine

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About This Item

Empirical Formula (Hill Notation):
C12H11N7
CAS Number:
396-01-0
Molecular Weight:
253.26
NACRES:
NA.77
PubChem Substance ID:
24277877
UNSPSC Code:
12352200
EC Number:
206-904-3
MDL number:
MFCD00006708
Assay:
≥99%
Quality level:
100
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Quality Level

100

assay

≥99%

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble 1.2 mg/mL, DMSO: soluble 5.4 mg/mL, H2O: insoluble

originator

Wellspring

SMILES string

Nc1nc(N)c2nc(-c3ccccc3)c(N)nc2n1

InChI

1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19)

InChI key

FNYLWPVRPXGIIP-UHFFFAOYSA-N

Gene Information

human ... SCNN1A(6337), SCNN1B(6338), SCNN1G(6340)

Application

Triamterene has been used to study its effects on urokinase receptor (uPAR) induction in podocytes under in vitro conditions2. Triamterene has also been identified as an activator compound from a LOPAC library screen using a fluorogenic α-glucosidase assay3.

Biochem/physiol Actions

Weak diuretic with potassium sparing properties; blocks Na+ reuptake in the kidneys.

Features and Benefits

This compound was developed by Wellspring. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

200 mg of triamterene is soluble in 4 ml of warm formic acid and yields a clear, yellow-green solution. Triamterene is also soluble in DMSO (5.4 mg/ml), and in 45% (w/v) aqueous 2-hydroxypropyl-β-cyclodextrin (1.2 mg/ml). However, it is insoluble in water.

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pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCJ8322
BCCG8637
BCCC3842
BCCB5415
BCCB3174

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Zhuomin Zhang et al.
The Analyst, 133(9), 1187-1194 (2008-08-19)
In competition sports, a diuretic is a substance widely prohibited by the World Anti-Doping Agency (WADA). In this paper, a sensitive, rapid and convenient analytical method for the determination of acidic [furosemide (FUROS) and bumetanide (BUMET)] and basic [triamterene (TRIAM)]
Yiqun Wu et al.
Clinical drug investigation, 31(11), 769-777 (2011-06-16)
A fixed-dose combination (FDC) of four compounds, hydrochlorothiazide 12.5 mg, triamterene 12.5 mg, dihydralazine 12.5 mg and reserpine 0.1 mg (HTDR), is widely used as an antihypertensive treatment in China. Although HTDR has been used in China for more than
Ali Asghar Ensafi et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 24(11), 1449-1454 (2008-11-11)
A square-wave voltammetric procedure for the electroanalytical determination of losartan and triamterene in Britton-Robinson buffer (pH 3.0, 0.1 mol L(-1)) as a supporting electrolyte containing 30 ng mL(-1) of copper ions was developed. Opposite to the case of triamterene, losartan
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