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Merck

26569

2-Chlorotrityl chloride

≥97.0% (AT)

Synonym(s):

Chloro(2-chlorophenyl)diphenylmethane

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About This Item

Empirical Formula (Hill Notation):
C19H14Cl2
CAS Number:
Molecular Weight:
313.22
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
255-647-3
Beilstein/REAXYS Number:
1983914
MDL number:

Product Name

2-Chlorotrityl chloride, ≥97.0% (AT)

InChI key

JFLSOKIMYBSASW-UHFFFAOYSA-N

InChI

1S/C19H14Cl2/c20-18-14-8-7-13-17(18)19(21,15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14H

SMILES string

Clc1ccccc1C(Cl)(c2ccccc2)c3ccccc3

assay

≥97.0% (AT)

form

solid

mp

130-135 °C

functional group

chloro
phenyl

Quality Level

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Application

2-Chlorotrityl chloride was used to obtain protected peptide fragments that can be applied to the preparation of head-to-tail cyclopeptides or to condensation of peptidic fragments.

Other Notes

Protecting group reagent for carboxylic acids forming esters which are cleaved mildly.

pictograms

CorrosionExclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Shinichiro F Ichise et al.
Acta biomaterialia, 94, 361-371 (2019-06-15)
Collagen is the most abundant protein in the animal kingdom and has a unique triple-helical structure. It not only provides mechanical strength to tissues, but also performs specific biological functions as a multifaceted signaling molecule. Animal-derived collagen is therefore widely
K Barlos et al.
International journal of peptide and protein research, 37(6), 513-520 (1991-06-01)
The esterification of 2-chlorotrityl chloride resin with Fmoc-amino acids in the presence of DIEA is studied under various conditions. High esterification yields are obtained using 0.6 equiv. Fmoc-amino acid/mmol resin in DCM or DCE, in 25 min, at room temperature.
Jie Luo et al.
Journal of the American Society for Mass Spectrometry, 30(9), 1643-1653 (2019-06-07)
Chemical cross-linking combined with mass spectrometry (CL-MS) is a powerful method for characterizing the architecture of protein assemblies and for mapping protein-protein interactions. Despite its proven utility, confident identification of cross-linked peptides remains a formidable challenge, especially when the peptides
Asker Y Khapchaev et al.
Journal of peptide science : an official publication of the European Peptide Society, 22(11-12), 673-681 (2016-10-05)
Myosin light chain kinase (MLCK) is a key regulator of various forms of cell motility including smooth muscle contraction, cell migration, cytokinesis, receptor capping, secretion, etc. Inhibition of MLCK activity in endothelial and epithelial monolayers using cell-permeant peptide Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys (PIK
Sogol Kangarlou et al.
Pharmaceutical biology, 55(1), 277-285 (2016-12-13)
Curcumin, a naturally occurring polyphenol, has been extensively studied for its broad-spectrum anticancer effects. The potential benefits are, however, limited due to its poor water solubility and rapid degradation which result in low bioavailability on administration. This study encapsulates curcumin

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