Skip to Content
Merck

C3878

Chlorogenic acid

≥95% (titration)

Synonym(s):

CGA, 1,4,5-Trihydroxycyclohexanecarboxylic acid 3-(3,4-dihydroxycinnamate), 3-(3,4-Dihydroxycinnamoyl)quinic acid

Sign In to View Organizational & Contract Pricing.

Select a Size

All Photos(4)

About This Item

Empirical Formula (Hill Notation):
C16H18O9
CAS Number:
327-97-9
Molecular Weight:
354.31
NACRES:
NA.22
PubChem Substance ID:
57654010
UNSPSC Code:
12352106
EC Number:
206-325-6
MDL number:
MFCD00003862

Product Name

Chlorogenic acid, ≥95% (titration)

InChI key

CWVRJTMFETXNAD-JUHZACGLSA-N

InChI

1S/C16H18O9/c17-9-3-1-8(5-10(9)18)2-4-13(20)25-12-7-16(24,15(22)23)6-11(19)14(12)21/h1-5,11-12,14,17-19,21,24H,6-7H2,(H,22,23)/b4-2+/t11-,12-,14-,16+/m1/s1

SMILES string

O[C@@H]1C[C@](O)(C[C@@H](OC(=O)\C=C\c2ccc(O)c(O)c2)[C@@H]1O)C(O)=O

assay

≥95% (titration)

form

powder

mp

210 °C (dec.) (lit.)

Quality Level

200

Gene Information

rat ... G6pc(25634)

Looking for similar products? Visit Product Comparison Guide

Application

  • Antioxidant and Phenolic Profiles: A study detailed the antioxidant and phenolic profiles of Thai medicinal plants, including chlorogenic acid, to support functional food and pharmaceutical development, highlighting its potential applications in enhancing food functionality and health benefits (Wanyo et al., 2024).
  • Intravesical Therapy for Cystitis: Research demonstrated the use of chlorogenic acid in intravesical therapy to modify acute voiding behavior in mice with systemic lipopolysaccharide inflammation-induced cystitis, suggesting therapeutic potential in bladder disorders (Yeh et al., 2024).
  • Cardioprotection in Chemotherapy: A hydroethanolic extract containing chlorogenic acid was investigated for its role in mitigating doxorubicin-induced cardiotoxicity through mitochondrial protection mediated by AMPK-PGC-1α-SOD, underscoring its potential in protective strategies against chemotherapy-induced cardiac damage (Song et al., 2024).
  • Nutritional Delivery and Food Industry: A review discussed chlorogenic acid′s role in nutrition delivery and its implications in the food industry, proposing its use as nanoparticles for active food packaging application. (Hu et al., 2024).

Disclaimer

May yield a hazy solution in ethanol

General description

Chlorogenic acid is a bioactive polyphenolic compound mainly found in many plants, such as coffee. It is a potent neuroprotectant and also possesses antiviral, antifungal, antioxidant and antitumor properties. CGA may also be involved in regulating glucose and lipid metabolism and improving insulin sensitivity.
Chlorogenic acid is a cinnamate ester used as a reducing agent and stabilizer in bimetallic nanoparticle synthesis.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
WXBF3738V
WXBF3768V
WXBF0913V
WXBD9324V
WXBD6046V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Chlorogenic acid and caffeic acid are absorbed in humans
Olthof MR
The Journal of Nutrition, 131(1), 66-71 (2001)
Controlled green synthesis of Au-Pt bimetallic nanoparticles using chlorogenic acid
Chen R, et al.
Research on Chemical Intermediates, 47, 4051-4066 (2021)
Chlorogenic acid and coffee prevent hypoxia-induced retinal degeneration
Jang H
Journal of Agricultural and Food Chemistry, 62(1), 182-191 (2013)
Roles of chlorogenic acid on regulating glucose and lipids metabolism: a review
Meng S
Evidence-Based Complementary and Alternative Medicine : ECAM (2013)
Mariam Jarouche et al.
Plants (Basel, Switzerland), 8(12) (2019-12-19)
Lycium (also known as Goji berry) is used in traditional Chinese medicine (TCM) with claimed benefits, including eye and liver protection, immune system fortification and blood glucose control. The commercially available product comes from either the L.barbarum or L.chinense species
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service