H8378

D-α-Hydroxyglutaric acid disodium salt

Name: <SC>D</SC>-α-Hydroxyglutaric acid disodium salt
Brand: ALDRICH

≥95% (GC), cell analysisfor peptide synthesis

Synonym(s):

(R)-2-Hydroxypentanedioic acid disodium salt, Disodium (R)-2-hydroxyglutarate

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All Photos(3)

About This Item

Linear Formula:

C₅H₆O₅Na₂

CAS Number:

103404-90-6

Molecular Weight:

192.08

NACRES:

NA.22

PubChem Substance ID:

57654274

UNSPSC Code:

12352106

MDL number:

MFCD00069573

Beilstein/REAXYS Number:

5318041

Product Name

D-α-Hydroxyglutaric acid disodium salt, ≥95% (GC)

InChI key

DZHFTEDSQFPDPP-HWYNEVGZSA-L

SMILES string

[Na].O[C@H](CCC(O)=O)C(O)=O

InChI

1S/C5H8O5.2Na/c6-3(5(9)10)1-2-4(7)8;;/h3,6H,1-2H2,(H,7,8)(H,9,10);;/q;2*+1/p-2/t3-;;/m1../s1

assay

≥95% (GC)

form

powder

color

white to off-white

application(s)

cell analysis
peptide synthesis

storage temp.

−20°C

Quality Level

200

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Related Categories

Amino Acids

Amino Acids, Resins & Reagents for Peptide Synthesis

Biochemicals

Cell Culture Supplements & Reagents

Building Blocks, Resins, and Coupling Reagents for GLP-1 Synthesis

Application

D-α-Hydroxyglutaric acid disodium salt can be used as a reagent in peptide synthesis.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.

Shan Jin et al.

Nature communications, 14(1), 6638-6638 (2023-10-21)

Mammalian lactate dehydrogenase D (LDHD) catalyzes the oxidation of D-lactate to pyruvate. LDHD mutations identified in patients with D-lactic acidosis lead to deficient LDHD activity. Here, we perform a systematic biochemical study of mouse LDHD (mLDHD) and determine the crystal

The tumor suppressor prostate apoptosis response-4 (Par-4) is regulated by mutant IDH1 and kills glioma stem cells.

Liu Y, Gilbert MR, Kyprianou N, et al.

Acta Neuropathologica, 128(5), 723-732 (2014)

2-hydroxyglutaryl-CoA dehydratase from Clostridium symbiosum.

M Hans et al.

European journal of biochemistry, 265(1), 404-414 (1999-09-22)

Component D (HgdAB) of 2-hydroxyglutaryl-CoA dehydratase from Clostridium symbiosum was purified to homogeneity. It is able to use component A from Acidaminococcus fermentans (HgdC) to initiate catalysis together with ATP, Mg2+ and a strong reducing agent such as Ti(III)citrate. Component

Mutant IDH Sensitizes Gliomas to Endoplasmic Reticulum Stress and Triggers Apoptosis via miR-183-Mediated Inhibition of Semaphorin 3E.

Ying Zhang et al.

Cancer research, 79(19), 4994-5007 (2019-08-09)

Human astrocytomas and oligodendrogliomas are defined by mutations of the metabolic enzymes isocitrate dehydrogenase (IDH) 1 or 2, resulting in the production of the abnormal metabolite D-2 hydroxyglutarate. Here, we studied the effect of mutant IDH on cell proliferation and

Postoperative risk of IDH mutant glioma-associated seizures and their potential management with IDH mutant inhibitors.

Drumm, et al.

The Journal of Clinical Investigation (2023)

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