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Merck

A3658

N8-Acetylspermidine dihydrochloride

analytical standard

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About This Item

Empirical Formula (Hill Notation):
C9H21N3O · 2HCl
CAS Number:
34450-15-2
Molecular Weight:
260.20
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329770841
MDL number:
MFCD00058263
Beilstein/REAXYS Number:
3698131

Key Documents

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Product Name

N8-Acetylspermidine dihydrochloride, analytical standard

InChI

1S/C9H21N3O.2ClH/c1-9(13)12-8-3-2-6-11-7-4-5-10;;/h11H,2-8,10H2,1H3,(H,12,13);2*1H

SMILES string

Cl.Cl.CC(=O)NCCCCNCCCN

InChI key

BWGUIRARVGYOIR-UHFFFAOYSA-N

grade

analytical standard

technique(s)

mass spectrometry (MS): suitable

format

neat

storage temp.

2-8°C

Quality Level

200

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pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000506332
0000506332
0000484565
0000484565
0000236746

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M Lurdes et al.
Acta chemica Scandinavica (Copenhagen, Denmark : 1989), 43(10), 990-994 (1989-11-01)
The synthesis of all three monoacetylated spermidines is reported. N4-Acetylspermidine was obtained in four steps from spermidine via the triacetylated intermediate by selective deacetylation after exhaustive t-butoxycarbonylation as well as directly from a previously described protected precursor. N1-Acetylspermidine and N8-acetylspermidine
J E Morgan et al.
Archives of biochemistry and biophysics, 246(1), 225-232 (1986-04-01)
The effect of Mg2+, putrescine, diaminopropane, N1-acetylspermidine, N8-acetylspermidine, spermidine, and spermine on the thermal denaturation of calf thymus DNA was investigated. As in a previous study with magnesium [W.F. Dove and N. Davidson, (1962) J. Mol. Biol. 5, 467-478], these
A Sessa et al.
Cancer letters, 76(2-3), 121-125 (1994-01-30)
N-ethyl-N-nitrosourea-induced rat gliomas showed a stimulation of cytosolic spermidine N-acetyltransferase activity compared with normal brain, with an increased formation of N1 and N8-acetylspermidine, suggesting the activation of two enzymes acetylating the polyamine in N1 and N8 position, respectively. The enhancement
Similarity of effects of N8-acetylspermidine and its deacetylase inhibitor on stimulating the growth of L1210 cells.
Z Wang et al.
Proceedings of the Western Pharmacology Society, 38, 41-43 (1995-01-01)
O P Shukla et al.
Molecular and biochemical parasitology, 51(1), 91-98 (1992-03-01)
Polyamine oxidase plays a key role in the catabolism of polyamines and regeneration of spermidine and putrescine. The mammalian enzyme utilises N1-acetylspermidine, and N8-acetylspermidine, although formed in the mammals, is not catabolised further. We have characterised an enzyme from Acanthamoeba
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