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Merck

D186309

Dimethyl sulfate

≥99.5%, liquid

Synonym(s):

Sulfuric acid dimethyl ester

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About This Item

Linear Formula:
(CH3O)2SO2
CAS Number:
77-78-1
Molecular Weight:
126.13
NACRES:
NA.21
PubChem Substance ID:
57654074
UNSPSC Code:
12352100
EC Number:
201-058-1
MDL number:
MFCD00008416
Beilstein/REAXYS Number:
635994

Product Name

Dimethyl sulfate, ≥99.5%

InChI key

VAYGXNSJCAHWJZ-UHFFFAOYSA-N

InChI

1S/C2H6O4S/c1-5-7(3,4)6-2/h1-2H3

SMILES string

COS(=O)(=O)OC

vapor density

4.3 (vs air)

vapor pressure

0.7 mmHg ( 25 °C)

assay

≥99.5%

form

liquid

autoignition temp.

923 °F

refractive index

n20/D 1.386 (lit.)

bp

188 °C (lit.)

mp

−32 °C (lit.)

density

1.333 g/mL at 25 °C (lit.)

Quality Level

200

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Application

Dimethyl sulfate may be used along with alumina for preparation of monomethylated derivatives of alcohols, phenols and carboxylic acids. It may also be used in combination with dimethylformamide (DMF) to form methoxy-methylene-N,N-dimethyliminium salt, that can be utilized for the preparation of β-lactams.

Packaging

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18 L in Kilo-Lab® packaging not available in all areas.
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Legal Information

Kilo-Lab is a registered trademark of Merck KGaA, Darmstadt, Germany

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Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Oral - Carc. 1B - Eye Dam. 1 - Muta. 2 - Skin Corr. 1B - Skin Sens. 1

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

181.4 °F - closed cup

flash_point_c

83 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
SHBS0779
SHBR4115
SHBP3232
SHBQ0585
SHBP9161

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A new method for sequencing DNA.
Maxam AM and Gilbert W.
Proceedings of the National Academy of Sciences of the USA, 74(2), 560-564 (1977)
Methylation of alcohols, phenols, and carboxylic acids, and selective monomethylation of diols and dicarboxylic acids with dimethyl sulfate by use of alumina.
Ogawa H, et al.
Bulletin of the Chemical Society of Japan, 59(8), 2481-2483 (1986)
DMF-dimethyl sulfate as a new reagent for the synthesis of β-lactams.
Jarrahpour A and Zarei M.
Tetrahedron Letters, 50(14), 1568-1570 (2009)
Chad M Kurylo et al.
Cell reports, 25(1), 236-248 (2018-10-04)
Prevailing dogma holds that ribosomes are uniform in composition and function. Here, we show that nutrient limitation-induced stress in E. coli changes the relative expression of rDNA operons to alter the rRNA composition within the actively translating ribosome pool. The most
Cecilia E Ström et al.
DNA repair, 10(9), 961-969 (2011-08-16)
CK2 phosphorylates the scaffold protein XRCC1, which is required for efficient DNA single-strand break (SSB) repair. Here, we express an XRCC1 protein (XRCC1(ckm)) that cannot be phosphorylated by CK2 in XRCC1 mutated EM9 cells and show that the role of
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