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Merck

T9159

Trichloroacetic acid

BioXtra, ≥99.0%

Synonym(s):

TCA

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About This Item

Linear Formula:
Cl3CCOOH
CAS Number:
Molecular Weight:
163.39
UNSPSC Code:
12352106
NACRES:
NB.22
PubChem Substance ID:
EC Number:
200-927-2
Beilstein/REAXYS Number:
970119
MDL number:

Product Name

Trichloroacetic acid, BioXtra, ≥99.0%

InChI key

YNJBWRMUSHSURL-UHFFFAOYSA-N

InChI

1S/C2HCl3O2/c3-2(4,5)1(6)7/h(H,6,7)

SMILES string

OC(=O)C(Cl)(Cl)Cl

grade

BioPerformance Certified

vapor density

<1 (vs air)

vapor pressure

1 mmHg ( 51 °C)

product line

BioXtra

assay

≥99.0%

impurities

≤0.0005% Phosphorus (P)
≤0.1% Insoluble matter

ign. residue

≤0.03%

refractive index

n20/D 1.62 (lit.)

bp

196 °C (lit.)

mp

54-58 °C (lit.)

solubility

H2O: 0.5 M at 20 °C, clear, colorless

density

1.62 g/mL at 25 °C (lit.)

anion traces

sulfate (SO42-): ≤0.05%

cation traces

Al: ≤0.0005%
Ca: ≤0.005%
Cu: ≤0.0005%
Fe: ≤0.001%
K: ≤0.01%
Mg: ≤0.0005%
NH4+: ≤0.05%
Na: ≤0.005%
Pb: ≤0.001%
Zn: ≤0.0005%

storage temp.

2-8°C

Quality Level

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Application

Traditionally used to precipitate protein. Has been used to determine protein concentration by quantitative precipitation. Used as decalcifier and fixative in microscopy.
Trichloroacetic acid has been used:
  • for protein precipitation
  • as a component in the extract solution used for the measurement of malondialdehyde and glutathione
  • to precipitate the transfected and treated cells in [3H]-thymidine incorporation assay

Biochem/physiol Actions

TCA might act as a carcinogen, targeting liver. It might be used as an acid decalcifying agent. TCA helps in nuclear staining.

General description

Trichloroacetic acid (TCA) is an important metabolic product of trichloroethylene (TCE) metabolism.

pictograms

CorrosionEnvironment

signalword

Danger

hcodes

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1A

Storage Class

8B - Non-combustible corrosive hazardous materials

wgk

WGK 2

flash_point_f

>235.4 °F - closed cup

flash_point_c

> 113 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


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Li J, et al.
The American Journal of Pathology, 184(2), 556-571 (2014)
Analysis of malondialdehyde, chlorophyll proline, soluble sugar, and glutathione content in Arabidopsis seedling
Zhang Z and Huang R
Bio-protocol, 3, e817-e817 (2013)
Histophatologic Techniques (2006)
Bo Chen et al.
Translational stroke research, 10(1), 91-103 (2018-03-24)
The transient receptor potential melastatin 4 (TRPM4) channel has been suggested to play a key role in the treatment of ischemic stroke. However, in vivo evaluation of TRPM4 channel, in particular by direct channel suppression, is lacking. In this study

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