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Merck

13433

Sodium bicarbonate

puriss., meets analytical specification of Ph. Eur., BP, USP, FCC, E500, 99.0-100.5%, powder

Synonym(s):

Sodium hydrogen carbonate

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About This Item

Linear Formula:
NaHCO3
CAS Number:
144-55-8
Molecular Weight:
84.01
NACRES:
NA.21
PubChem Substance ID:
329750171
eCl@ss:
38020213
UNSPSC Code:
12352302
EC Number:
205-633-8
MDL number:
MFCD00003528
Beilstein/REAXYS Number:
4153970
Assay:
99.0-100.5%
Form:
powder

Key Documents

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InChI key

UIIMBOGNXHQVGW-UHFFFAOYSA-M

InChI

1S/CH2O3.Na/c2-1(3)4;/h(H2,2,3,4);/q;+1/p-1

SMILES string

[Na+].OC([O-])=O

grade

puriss.

assay

99.0-100.5%

form

powder

quality

meets analytical specification of Ph. Eur., BP, USP, FCC, E500

impurities

ammonia (NH3), in accordance, organic volatile impurities, complies, residual solvents, complies, water-insoluble matter, complies, ≤0.002% ammonium (NH4), complies

loss

≤0.2% loss on drying (silica gel)

pH

≤8.6 (20 °C, 5%)

pKa (25 °C)

(1) 6.37, (2) 10.25 (carbonic acid)

density

2.16 g/mL at 25 °C (lit.)

anion traces

carbonate (CO32-): in accordance, chloride (Cl-): ≤100 mg/kg, sulfate (SO42-): ≤100 mg/kg

cation traces

Al: ≤0.5 mg/kg, As: ≤2 mg/kg, Ca: ≤100 mg/kg, Fe: ≤10 mg/kg, Hg: ≤1 mg/kg, K: ≤100 mg/kg, Pb: ≤2 mg/kg

suitability

complies for appearance of solution

Quality Level

200

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Application

Sodium bicarbonate may be involved in the fabrication of silica based monolith columns which can be used in capillary electrochromatography. It can also be used to maintain the pH of the column for the separation of proteins via ion exchange displacement chromatography.

Storage Class

13 - Non Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCZ7043
MKCZ1503
MKCX8760
MKCX8206
MKCX6007

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Silica-based monoliths for capillary electrochromatography: Methods of fabrication and their applications in analytical separations
Allen D and Rassi EZ
Electrophoresis, 24, 3962-3976 (2003)
Use of the sodium salt of poly (vinylsulfonic acid) as a low-molecular-weight displacer for protein separations by ion-exchange displacement chromatography
Jen D.C.S and Pinto.GN
Journal of Chromatography A, 519(1), 87-98 (1990)
Shay P McGuinness et al.
Critical care medicine, 41(7), 1599-1607 (2013-05-21)
Cardiac surgery-associated acute kidney injury occurs in up to 50% of patients and is associated with increased mortality and morbidity. This study aimed to discover if perioperative urinary alkalinization with sodium bicarbonate infusion reduces the prevalence of cardiac surgery-associated acute
Sophia Zoungas et al.
Annals of internal medicine, 151(9), 631-638 (2009-11-04)
Intravenous sodium bicarbonate has been proposed to reduce the risk for contrast-induced nephropathy (CIN). To determine the effect of sodium bicarbonate on the risk for CIN. MEDLINE, PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials from 1950 to
Eric A J Hoste et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 25(3), 747-758 (2009-08-26)
There have been conflicting reports on the use of intravenous administration of sodium bicarbonate for prevention of contrast-induced acute kidney injury (CI-AKI). The aim of this study was to evaluate the use of sodium bicarbonate for prevention of CI-AKI. This
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