Skip to Content
Merck

A3940

1-Aminobenzotriazole

greener alternative

≥98% (TLC), powder, cytochrome P450 inhibitor

Synonym(s):

1-Benzotriazolamine, ABT

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C6H6N4
CAS Number:
1614-12-6
Molecular Weight:
134.14
NACRES:
NA.77
PubChem Substance ID:
24278226
UNSPSC Code:
12352200
MDL number:
MFCD00132902
Beilstein/REAXYS Number:
607843

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

1-Aminobenzotriazole,

InChI

1S/C6H6N4/c7-10-6-4-2-1-3-5(6)8-9-10/h1-4H,7H2

SMILES string

Nn1nnc2ccccc12

InChI key

JCXKHYLLVKZPKE-UHFFFAOYSA-N

assay

≥98% (TLC)

form

powder

greener alternative product score

old score: 93
new score: 46
Find out more about DOZN™ Scoring

greener alternative product characteristics

Waste Prevention
Safer Solvents and Auxiliaries
Inherently Safer Chemistry for Accident Prevention
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

mp

81-84 °C (lit.)

solubility

ethanol: 49-51 mg/mL, clear, pale yellow to yellow

greener alternative category

, Re-engineered

Quality Level

200

Gene Information

human ... CYP1A2(1544)

Looking for similar products? Visit Product Comparison Guide

Related Categories

Application

1-Aminobenzotriazole has been used as a cytochrome P450 inhibitor to study the effects of estrogen on H2O2-induced premature senescence of vascular smooth muscle cells from old rats It has also been used to study the estrogen receptor-mediated effects of 17β-estradiol.

Biochem/physiol Actions

1-Aminobenzotriazole (1-ABT) is used as an in vitro tool in drug discovery. It can differentiate the P450 from non-P450 enzyme systems. 1-ABT exhibits inhibitory action by covalent alteration of the heme prosthetic group in the P450 enzyme.
Suicide inhibitor of cytochrome P450 and chloroperoxidase.

General description

We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives. This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles “Waste Prevention”, “Safer Solvents and Auxiliaries” and “Inherently Safer Chemistry for Accident Prevention”. Click here to view its DOZN scorecard.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000486014
0000486014
0000420467
0000420467
0000401293

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Effects of estrogen on stress-induced premature senescence of vascular smooth muscle cells: a novel mechanism for the ?time window theory? of menopausal hormone therapy
Zhu C, et al.
Atherosclerosis, 215(2), 294-300 (2011)
M Lizeth Orozco Morales et al.
iScience, 25(1), 103571-103571 (2022-01-06)
Mesothelioma is a cancer that typically originates in the pleura of the lungs. It rapidly invades the surrounding tissues, causing pain and shortness of breath. We compared cell lines injected either subcutaneously or intrapleurally and found that only the latter
Is 1-aminobenzotriazole an appropriate in vitro tool as a nonspecific cytochrome P450 inactivator?
Linder CD, et al.
Drug Metabolism and Disposition, 37(1), 10-13 (2009)
Ailette Prieto et al.
Bioresource technology, 102(23), 10987-10995 (2011-09-23)
More than 90% of the antibiotics ciprofloxacin (CIPRO) and norfloxacin (NOR) at 2 mg L(-1) were degraded by Trametes versicolor after 7 days of incubation in malt extract liquid medium. In in vitro assays with purified laccase (16.7 nkat mL(-1))
Congli Zhu et al.
Atherosclerosis, 215(2), 294-300 (2011-02-09)
To investigate the effects of estrogen on stress-induced premature senescence of vascular smooth muscle cells (VSMCs) and the underlying mechanisms. VSMCs of passage 2-3 cultured from young (2 months) and old (18 months) female SD rats were induced into premature
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service