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E5156

Epinastine hydrochloride

Name: Epinastine hydrochloride
Brand: SIGMA

≥98% (HPLC), H1 histamine receptor antagonist, solid

Synonym(s):

9,13b-Dihydro-1H-dibenz[cf]imidazo[1,5-a]azepine hydrochloride, WAL-801Cl

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₅N₃ · HCl

CAS Number:

108929-04-0

Molecular Weight:

285.77

UNSPSC Code:

12352200

PubChem Substance ID:

24894608

NACRES:

NA.77

MDL number:

MFCD00933434

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

desiccated

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Properties

Product Name

Epinastine hydrochloride, ≥98% (HPLC), solid

Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

white

solubility

H₂O: 38 mg/mL

originator

Boehringer Ingelheim

storage temp.

2-8°C

SMILES string

Cl[H].NC1=NCC2N1c3ccccc3Cc4ccccc24

InChI

1S/C16H15N3.ClH/c17-16-18-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)19(15)16;/h1-8,15H,9-10H2,(H2,17,18);1H

InChI key

VKXSGUIOOQPGAF-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

Description

General description

Epinastine has antihistamine functions. In mast cells, it may modulate cytokine and chemokine production. In dendritic cells, it controls T helper cell mediated immune response. Epinastine hydrochloride does not traverse the brain barrier. Oral dosage of epinastine hydrochloride is prescribed for children with sleep-disordered breathing (SDB) and nasal inflammation. Ophthalmic solution of epinastine is effective for allergic conjunctivitis.

Biochem/physiol Actions

Epinastine hydrochloride is a non-sedating H1 histamine receptor antagonist.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Inhibition of angiogenic factor production from murine mast cells by an antiallergic agent (epinastine hydrochloride) in vitro

Asano K, et al.

Mediators of Inflammation, 2008 (2008)

Population pharmacokinetics of epinastine, a histamine H1 receptor antagonist, in adults and children

Sarashina A, et al.

British Journal of Clinical Pharmacology, 59(1), 43-53 (2005)

Influence of epinastine hydrochloride, an H1-receptor antagonist, on the function of mite allergen-pulsed murine bone marrow-derived dendritic cells in vitro and in vivo

Oshima KZ, et al.

Mediators of Inflammation, 2009 (2009)

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