Key Documents

View All Documentation

F9803

FTI-277 trifluoroacetate salt

Name: FTI-277 trifluoroacetate salt
Brand: SIGMA

≥95% (HPLC), film

Synonym(s):

N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl]methionine methyl ester trifluoroacetate salt

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₂₂H₂₉N₃O₃S₂ · xC₂HF₃O₂

CAS Number:

170006-73-2

Molecular Weight:

447.61 (free base basis)

NACRES:

NA.77

PubChem Substance ID:

329799790

UNSPSC Code:

51111800

MDL number:

MFCD06795840

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Quality Level

100

assay

≥95% (HPLC)

form

film

storage condition

desiccated

solubility

H₂O: ≥2 mg/mL

shipped in

dry ice

storage temp.

−70°C

SMILES string

OC(=O)C(F)(F)F.COC(=O)[C@H](CCSC)NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c2ccccc2

InChI

1S/C22H29N3O3S2.C2HF3O2/c1-28-22(27)20(10-11-30-2)25-21(26)18-9-8-17(24-13-16(23)14-29)12-19(18)15-6-4-3-5-7-15;3-2(4,5)1(6)7/h3-9,12,16,20,24,29H,10-11,13-14,23H2,1-2H3,(H,25,26);(H,6,7)/t16-,20+;/m1./s1

InChI key

GJEFFRDWFVSCOJ-PXPMWPIZSA-N

Description

Application

Farnesyltransferase inhibitor 277 (FTI-277) has been used to:

inhibit protein farnesylation in breast cell lines.
in marrow-isolated adult multilineage inducible cells (MIAMI).
inhibition of farnesyl transferase in CV-1 in Origin with SV40 genes cells (COS-7).

Biochem/physiol Actions

Highly potent (pM/nM) Ras CAAX peptidomimetic which antagonizes both H and K-Ras oncogenic signaling. Inhibitor of farnesyltransferase (Ftase) IC₅₀= 50 nM.

Farnesyltransferase inhibitor 277 (FTI-277) mediates apoptosis in multiple myeloma and is regarded as a potential therapeutic agent.

Packaging

Very hygroscopic material, package in a dry room with deoxygenated MeOH and pump down the solvent. Store with desiccant.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Endothelial protective genes induced by statin is mimicked by FTI-277 and GGTI-298 drug combination-mediated ERK5 activation

Chu UB, et al.

Biochimica et Biophysica Acta, 1850(7), 1415-1425 (2015)

A chemokine regulatory loop induces cholesterol synthesis in lung-colonizing triple-negative breast cancer cells to fuel metastatic growth.

Bingchen Han et al.

Molecular therapy : the journal of the American Society of Gene Therapy, 30(2), 672-687 (2021-07-19)

Triple-negative breast cancer (TNBC) has a high propensity for organ-specific metastasis. However, the underlying mechanisms are not well understood. Here we show that the primary TNBC tumor-derived C-X-C motif chemokines 1/2/8 (CXCL1/2/8) stimulate lung-resident fibroblasts to produce the C-C motif

Progerin expression disrupts critical adult stem cell functions involved in tissue repair

Pacheco LM, et al.

Aging (Albany. NY.), 6(12), 1049-1063 (2014)

View All Related Papers