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Merck

G6416

GW5074

powder

Synonym(s):

3-(3,5-Dibromo-4-hydroxybenzyliden)-5-iodo-1,3-dihydroindol-2-one

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About This Item

Empirical Formula (Hill Notation):
C15H8Br2INO2
CAS Number:
220904-83-6
Molecular Weight:
520.94
NACRES:
NA.77
PubChem Substance ID:
24278455
UNSPSC Code:
12352200
MDL number:
MFCD03453076

Product Name

GW5074, powder

InChI key

LMXYVLFTZRPNRV-KMKOMSMNSA-N

SMILES string

Oc1c(Br)cc(cc1Br)\C=C2/C(=O)Nc3ccc(I)cc23

InChI

1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3-

assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

yellow to orange-brown

solubility

DMSO: 5 mg/mL, clear

storage temp.

room temp

Quality Level

100

Gene Information

human ... RAF1(5894)

Related Categories

Application

GW5074 has been used as a specific inhibitor of cRaf1 in C2 murine skeletal myoblasts, HT-29 colorectal adenocarcinoma cell line and neutrophils.

Biochem/physiol Actions

GW5074 is a cRaf1 kinase inhibitor, which is placed immediately downstream of Ras in the Motogen activated protein kinase (MAPK) signaling pathway. It elicits protection in GW5074 prevents degeneration in Huntington′s disease and also have therapeutic potential in treating neurodegenerative disorders. GW5074 in combination with anti-inflammatory drug, dexamethasone, attenuates sidestream smoke-induced airway inflammation.

Legal Information

Sold for research purposes under agreement from Glaxo­Smith­Kline

Other Notes

light sensitive

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000463891
0000463891
0000266273
0000236886
0000266273

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The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism
Chin PC, et al.
Journal of Neurochemistry, 90(3), 595-608 (2004)
Human intestinal epithelial cells respond to beta-glucans via Dectin-1 and Syk
Cohen-Kedar S, et al.
European Journal of Immunology, 44(12), 3729-3740 (2014)
Entamoeba histolytica induce signaling via Raf/MEK/ERK for neutrophil extracellular trap (NET) formation
Fonseca Z, et al.
Frontiers in Cellular and Infection Microbiology, 8(12), 226-226 (2018)
Tomoko Nishimura et al.
PloS one, 3(7), e2558-e2558 (2008-07-04)
Selective serotonin reuptake inhibitors (SSRIs) have been widely used and are a major therapeutic advance in psychopharmacology. However, their pharmacology is quite heterogeneous. The SSRI fluvoxamine, with sigma-1 receptor agonism, is shown to potentiate nerve-growth factor (NGF)-induced neurite outgrowth in
Yuan Zhang et al.
Scientific reports, 7(1), 10385-10385 (2017-09-06)
Enterovirus 71 (EV71) is a major pathogen of hand, foot, and mouth disease (HFMD). To date, no antiviral drug has been approved to treat EV71 infection. Due to the essential role that EV71 3 C protease (3C
View All Related Papers

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