K2628
Ketotifen fumarate salt
≥99% (TLC), powder, H₁ histamine receptor antagonist
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About This Item
Empirical Formula (Hill Notation):
C19H19NOS · C4H4O4
CAS Number:
Molecular Weight:
425.50
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
252-100-0
MDL number:
Form:
powder
Quality level:
Product Name
Ketotifen fumarate salt,
form
powder
Quality Level
originator
Novartis
SMILES string
OC(=O)\C=C\C(O)=O.CN1CCC(\CC1)=C2/c3ccccc3CC(=O)c4sccc24
InChI
1S/C19H19NOS.C4H4O4/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19;5-3(6)1-2-4(7)8/h2-5,8,11H,6-7,9-10,12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
InChI key
YNQQEYBLVYAWNX-WLHGVMLRSA-N
Gene Information
human ... HRH1(3269), PDE7B(27115)
General description
Ketotifen fumarate salt is an antihistamine drug.
Application
Ketotifen fumarate salt has been used: for mast cell product antagonism, as a positive control in β-hexosaminidase release assay, as mast cell stabilizer to treat pregnant dams added to ad libitum drinking water
Biochem/physiol Actions
H1 histamine receptor antagonist.
Ketotifen fumarate plays a key role in preventing histamine release by blocking the histamine H1 receptors. It interferes with the release of histamine, serotonin and other inflammatory mediators from mast cells. It exhibits with anti-allergic activity, anti-inflammatory effects including mast cell stabilization. It has been widely used for ophthalmic allergic conjunctivitis.
Features and Benefits
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Katsuya Unno et al.
European journal of pharmacology, 683(1-3), 179-185 (2012-03-28)
First generation H₁ histamine receptor antagonists, such as d-chlorpheniramine (d-CPA) and diphenhydramine, produce drowsiness in humans. They are currently used as over-the-counter sleep aids. However, the mechanisms underlying drowsiness induced by these H₁ histamine receptor antagonists remain obscure because they
Jing Wang et al.
Diabetes/metabolism research and reviews, 27(8), 919-924 (2011-11-10)
Mast cells are essential in allergic responses and beyond. White adipose tissue from obese humans contains large numbers of mast cells. Serum mast cell tryptase levels are also significantly higher in obese subjects than in lean subjects, suggesting a role
Anthony Soluri et al.
Optometry and vision science : official publication of the American Academy of Optometry, 89(8), 1140-1149 (2012-07-10)
To investigate the uptake and delivery of the anti-allergy drug ketotifen fumarate (KF) by commercially available contact lenses. A total of 14 different commercially available contact lenses were investigated, including five frequent-replacement silicone hydrogels, three conventional hydrogels, and six daily