SML0067
IOX1
≥97% (HPLC)
Synonym(s):
5-Carboxy-8-hydroxyquinoline, 8-Hydroxy-5-quinolinecarboxylic acid
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About This Item
Empirical Formula (Hill Notation):
C10H7NO3
CAS Number:
Molecular Weight:
189.17
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Product Name
IOX1, ≥97% (HPLC)
InChI
1S/C10H7NO3/c12-8-4-3-7(10(13)14)6-2-1-5-11-9(6)8/h1-5,12H,(H,13,14)
SMILES string
OC(=O)c1ccc(O)c2ncccc12
InChI key
JGRPKOGHYBAVMW-UHFFFAOYSA-N
assay
≥97% (HPLC)
form
powder
color
white to brown
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
Related Categories
Application
IOX1 has been used:
- To eliminate viral latency in latent viruses in order to sensitize the viral infections to antiviral therapy.
- In histone lysine demethylase 4A (KDM4A) inhibition, to serve as a unique strategy to decrease hypoxia-inducible factors signalling.
- to restore oncogene-induced senescence in wild-type mouse embryo fibroblasts.
Biochem/physiol Actions
Broad spectrum 2-oxoglutarate (2OG) oxygenase inhibitor.
IOX1 (5-Carboxy-8-hydroxyquinoline) is a broad spectrum inhibitor of 2-oxoglutarate (2OG) oxygenases, including Jumonji C domain (JmjC) demethylases. It is useful for the study of histone demethylation and hypoxic sensing and results in translocation of active site iron on the 2OG oxygenases. For full characterization details, please visit the IOX1 probe summary on the Structural Genomics Consortium (SGC) website.
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
IOX1 has an IC50 value as 200nM. IOX1 might be used in the treatment of β-thalassemia by α-globin downregulation.
Features and Benefits
IOX1 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Acetylation of intragenic histones on HPV16 correlates with enhanced HPV16 gene expression
Johansson C, et al.
Virology, 482(3), 244-259 (2015)
Epigenetic Cancer Therapy, 453-453 (2015)
Wenyu Yu et al.
Analytical biochemistry, 463, 54-60 (2014-07-11)
Covalent modifications, such as methylation and demethylation of lysine residues in histones, play important roles in chromatin dynamics and the regulation of gene expression. The lysine demethylases (KDMs) catalyze the demethylation of lysine residues on histone tails and are associated
Selective silencing of alpha-globin by the histone demethylase inhibitor IOX1: a potentially new pathway for treatment of beta-thalassemia
Mettananda S, et al.
Haematologica, 102(3), e80-e84 (2017)
Tian Tian et al.
Experimental and therapeutic medicine, 21(3), 180-180 (2021-01-26)
The aim of the present study was to investigate the effect of the histone H3K9 demethylase inhibitor, IOX1, on the mechanism of hepatic fibrosis in TGF-β-induced human hepatic stellate LX-2 cells. Cellular proliferation, apoptosis, histone H3K9 dimethylation (H3K9me2), protein expression
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