T3516

Thioflavin T

Name: Thioflavin T
Brand: SIGMA

Powder

Synonym(s):

Basic Yellow 1, Thioflavine T

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All Photos(4)

About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₉ClN₂S

CAS Number:

2390-54-7

Molecular Weight:

318.86

UNSPSC Code:

12171500

NACRES:

NA.47

PubChem Substance ID:

24900146

EC Number:

219-228-9

MDL number:

MFCD00011944

Colour Index Number:

49005

Beilstein/REAXYS Number:

3922452

Product Name

Thioflavin T, used as stain for amyloid

InChI

1S/C17H19N2S.ClH/c1-12-5-10-15-16(11-12)20-17(19(15)4)13-6-8-14(9-7-13)18(2)3;/h5-11H,1-4H3;1H/q+1;/p-1

InChI key

JADVWWSKYZXRGX-UHFFFAOYSA-M

SMILES string

[Cl-].CN(C)c1ccc(cc1)-c2sc3cc(C)ccc3[n+]2C

form

powder

composition

Dye content, ≥65%

solubility

methanol: 1 mg/mL

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

Quality Level

200

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Related Categories

Clinical & Diagnostics

Hematology Stains

Histology Stains

Tissue Diagnostics

Application

Thioflavin T has been used to identify the presence of amyloid fibrils in samples.

General description

Thioflavin T is a benzothiazole dye that increases in fluorescence upon binding to amyloid. Thioflavin T has been used in histology and for protein characterization.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

pictograms

GHS06,GHS05,GHS09

signalword

Danger

hcodes

H301,H317,H318,H410

pcodes

P261 - P273 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Sens. 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Tracking Aggregation and Fibrillation of Globular Proteins Using Terahertz and Far-Infrared Spectroscopies

Gretel Png

Taiwan yi Xue Hui za Zhi. Journal of the Formosan Medical Association (2016)

The epididymal amyloid matrix: structure and putative functions.

G A Cornwall et al.

Andrology, 7(5), 603-609 (2019-01-22)

We previously demonstrated the normal mouse epididymal lumen contains a non-pathological amyloid matrix that surrounds spermatozoa and plays important roles in sperm maturation and protection. The objective herein was to present a review of this work, including studies showing the

Mechanism of thioflavin T binding to amyloid fibrils.

Ritu Khurana et al.

Journal of structural biology, 151(3), 229-238 (2005-08-30)

Thioflavin T is a benzothiazole dye that exhibits enhanced fluorescence upon binding to amyloid fibrils and is commonly used to diagnose amyloid fibrils, both ex vivo and in vitro. In aqueous solutions, thioflavin T was found to exist as micelles

A DNA nanoswitch-controlled reversible nanosensor.

Pai Peng et al.

Nucleic acids research, 45(2), 541-546 (2016-12-03)

We present a conceptually new reversible nanosensor regulated by a DNA nanoswitch. This system is not only responsive to external stimuli (e.g. ATP) but also can be reversibly switched between 'OFF' and 'ON' states via toehold mediated strand displacement reactions.

Extrinsic fluorescent dyes as tools for protein characterization.

Hawe, A., et al.

Pharmaceut. Res., 25, 1487-1499 (2008)

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