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Merck

1705006

USP

L-Tyrosine

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

(S)-2-Amino-3-(4-hydroxyphenyl)propionic acid, 3-(4-Hydroxyphenyl)-L-alanine

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About This Item

Linear Formula:
4-(HO)C6H4CH2CH(NH2)CO2H
CAS Number:
60-18-4
Molecular Weight:
181.19
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329751451
MDL number:
MFCD00002606
Beilstein/REAXYS Number:
392441

Product Name

L-Tyrosine, United States Pharmacopeia (USP) Reference Standard

InChI key

OUYCCCASQSFEME-QMMMGPOBSA-N

InChI

1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1

SMILES string

N[C@@H](Cc1ccc(O)cc1)C(O)=O

grade

pharmaceutical primary standard

API family

tyrosine

form

fine crystals

manufacturer/tradename

USP

mp

>300 °C (dec.) (lit.)

application(s)

USP Biologics
pharmaceutical (small molecule)

format

neat

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Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

ʟ-Tyrosine USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Tyrosine
  • Glycyl-l-tyrosine
  • Levodopa
  • N-Acetyltyrosine
  • Hyaluronidase Injection

General description

ʟ-Tyrosine is a non-essential amino acid involved in the biosynthesis of catecholamines, thyroid hormones, and melanin. The USP ʟ-Tyrosine standard guarantees the purity and quality of this amino acid, supporting its use in peptide synthesis, cell culture media, and therapeutic development.

The United States Pharmacopeia (USP) provides quality standards for biologics to ensure their safety, efficacy, and quality throughout the manufacturing process. These standards assist manufacturers in adhering to regulatory requirements and help safeguard public health by reducing risks associated with biologics.

Other Notes

Amino acid precursor of dopamine and other catecholamines
Sales restrictions may apply.
This product is part of USP Biologics Program.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Storage Class

13 - Non Combustible Solids

wgk

WGK 1

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Maria B Feeney et al.
Antioxidants & redox signaling, 17(11), 1571-1579 (2012-03-20)
The understanding of physiological and pathological processes involving protein oxidation, particularly under conditions of aging and oxidative stress, can be aided by proteomic identification of proteins that accumulate oxidative post-translational modifications only if these detected modifications are connected to functional
Vincent Dunet et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 53(2), 207-214 (2012-02-04)
For the past decade, PET with (18)F-fluoro-ethyl-tyrosine ((18)F-FET) has been used in the evaluation of patients with primary brain tumors (PBTs), but so far series have reported only a limited number of patients. The purpose of this systematic review and
Verena Rahm et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(4), 546-550 (2014-02-26)
Low-grade gliomas (LGGs) may harbor malignant foci, which are characterized by increased tumor cellularity and angiogenesis. We used diffusion-weighted MR imaging (apparent diffusion coefficient [ADC]) and PET with the amino acid O-(2-(18)F-fluorethyl)-L-tyrosine ((18)F-FET) to search for focal changes of diffusion
Luis-Alberto Pérez-Quintero et al.
The Journal of experimental medicine, 211(4), 727-742 (2014-04-02)
Ewing's sarcoma-associated transcript 2 (EAT-2) is an Src homology 2 domain-containing intracellular adaptor related to signaling lymphocytic activation molecule (SLAM)-associated protein (SAP), the X-linked lymphoproliferative gene product. Both EAT-2 and SAP are expressed in natural killer (NK) cells, and their
Daniel T Patton et al.
Journal of immunology (Baltimore, Md. : 1950), 193(7), 3446-3455 (2014-08-22)
IL-7 is critical for murine T and B cell development and survival and plays a significant role in lymphoblastic leukemia in both humans and mice. We evaluated the role of the IL-7Rα Tyr(449) cytoplasmic SH2-binding motif in IL-7-mediated B cell
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