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W290904

Piperine

Name: Piperine
Brand: ALDRICH

≥95%, FG

Sinónimos:

1-Piperoylpiperidine

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Fórmula empírica (notación de Hill):

C₁₇H₁₉NO₃

Número CAS:

94-62-2

Peso molecular:

285.34

FEMA Number:

2909

Council of Europe no.:

492

UNSPSC Code:

12164502

PubChem Substance ID:

24901388

Flavis number:

14.003

EC Number:

202-348-0

NACRES:

NA.21

MDL number:

MFCD00005839

Beilstein/REAXYS Number:

90741

Organoleptic:

fatty; pepper

Grade:

FG, Halal, Kosher

Biological source:

Piper nigrum L.

Food allergen:

no known allergens

Servicio técnico

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Propiedades

biological source

Piper nigrum L.

Quality Level

400

grade

FG, Halal, Kosher

reg. compliance

EU Regulation 1334/2008 & 178/2002, FDA 21 CFR 172.515

assay

≥95%

form

powder, crystals or granules

mp

131-135 °C (lit.)

application(s)

flavors and fragrances

documentation

see Safety & Documentation for available documents

food allergen

no known allergens

organoleptic

fatty; pepper

SMILES string

O=C(\C=C\C=C\c1ccc2OCOc2c1)N3CCCCC3

InChI

1S/C17H19NO3/c19-17(18-10-4-1-5-11-18)7-3-2-6-14-8-9-15-16(12-14)21-13-20-15/h2-3,6-9,12H,1,4-5,10-11,13H2/b6-2+,7-3+

InChI key

MXXWOMGUGJBKIW-YPCIICBESA-N

Gene Information

human ... CYP3A4(1576)

Descripción

Biochem/physiol Actions

Piperine, a major component of black pepper extracts, shown to have potential for inhibiting fat cell formation.

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pictograms

GHS07,GHS09

signalword

Warning

hcodes

H302,H411

pcodes

P264 - P270 - P273 - P301 + P312 - P391 - P501

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Contenido relacionado

Halal Certificate

Kosher Certificate

HPLC-based activity profiling: discovery of piperine as a positive GABA(A) receptor modulator targeting a benzodiazepine-independent binding site.

Janine Zaugg et al.

Journal of natural products, 73(2), 185-191 (2010-01-21)

A plant extract library was screened for GABA(A) receptor activity making use of a two-microelectrode voltage clamp assay on Xenopus laevis oocytes. An ethyl acetate extract of black pepper fruits [Piper nigrum L. (Piperaceae) 100 microg/mL] potentiated GABA-induced chloride currents

Piperine, a component of black pepper, inhibits adipogenesis by antagonizing PPARγ activity in 3T3-L1 cells.

Ui-Hyun Park et al.

Journal of agricultural and food chemistry, 60(15), 3853-3860 (2012-04-03)

This study investigated the antiadipogenic activity of black pepper extract and its constituent piperine in 3T3-L1 preadipocytes as well as the underlying molecular mechanisms. Both black pepper extract and piperine, without affecting cytotoxicity, strongly inhibited the adipocyte differentiation of 3T3-L1

Piperine, an LXRα antagonist, protects against hepatic steatosis and improves insulin signaling in mice fed a high-fat diet.

Hyejeong Jwa et al.

Biochemical pharmacology, 84(11), 1501-1510 (2012-09-25)

This study investigated the role of piperine in the transcriptional regulation of liver X receptor α (LXRα) and the effects of dietary piperine on high-fat diet (HFD)-induced hepatic steatosis and insulin resistance in mice. Furthermore, we explored the potential molecular

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