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Fórmula empírica (notación de Hill):
C27H46O2
Número CAS:
Peso molecular:
402.65
UNSPSC Code:
12352211
NACRES:
NA.25
Servicio técnico
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Permítanos ayudarledescription
cholest-5-ene-3β,4β-diol
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 10 mg (700036P-10mg), pkg of 1 × 5 mg (700036P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
SMILES string
OC1CCC2(C3C(C4C(C(CC4)C(CCCC(C)C)C)(CC3)C)CC=C2C1O)C
InChI
1S/C27H46O2/c1-17(2)7-6-8-18(3)20-11-12-21-19-9-10-23-25(29)24(28)14-16-27(23,5)22(19)13-15-26(20,21)4/h10,17-22,24-25,28-29H,6-9,11-16H2,1-5H3
InChI key
CZDKQKOAHAICSF-UHFFFAOYSA-N
General description
4β-hydroxycholesterol is an endogenous oxysterol, which is formed by cytochrome P450 3A (CYP3A4) and CYP3A5.
Biochem/physiol Actions
4β-hydroxycholesterol acts as a marker for cytochrome P450 3A (CYP3A4/5) activity.
Packaging
5 mL Amber Glass Screw Cap Vial (700036P-10mg)
5 mL Amber Glass Screw Cap Vial (700036P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Clase de almacenamiento
11 - Combustible Solids
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4beta-hydroxycholesterol as an endogenous marker for CYP3A4/5 activity. Stability and half-life of elimination after induction with rifampicin
Diczfalusy U, et al.
British Journal of Clinical Pharmacology, 67(1), 38-43 (2009)
Michael E Abrams et al.
Nature microbiology, 5(7), 929-942 (2020-04-15)
Cholesterol 25-hydroxylase (CH25H) is an interferon-stimulated gene that converts cholesterol to the oxysterol 25-hydroxycholesterol (25HC). Circulating 25HC modulates essential immunological processes including antiviral immunity, inflammasome activation and antibody class switching; and dysregulation of CH25H may contribute to chronic inflammatory disease