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840029P

Avanti

18:0 PS

Avanti Research™ - A Croda Brand

Sinónimos:

1,2-dioctadecanoyl-sn-glycero-3-phospho-L-serine (sodium salt); DSPS; PS(18:0/18:0); 110671

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Fórmula empírica (notación de Hill):
C42H81NO10PNa
Número CAS:
321595-13-5
Peso molecular:
814.06
MDL number:
MFCD00145110
UNSPSC Code:
12352211
NACRES:
NA.25
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description

1,2-distearoyl-sn-glycero-3-phospho-L-serine (sodium salt)

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 10 mg (840029P-10mg), pkg of 1 × 25 mg (840029P-25mg), pkg of 1 × 500 mg (840029P-500mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

lipid type

cardiolipins
phospholipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OC[C@](C([O-])=O)([H])[NH3+])=O)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[Na+]

InChI

1S/C42H82NO10P.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(44)50-35-38(36-51-54(48,49)52-37-39(43)42(46)47)53-41(45)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;/h38-39H,3-37,43H2,1-2H3,(H,46,47)(H,48,49);/q;+1/p-1/t38-,39+;/m1./s1

InChI key

SJRBMGBLPUBGJL-MBAWARMDSA-M

General description

Phosphatidylserine (PS), an aminophospholipid is negatively charged and accounts for 2–10% of total cellular lipid. It is located in the membrane leaflets.

Application

18:0 PS has been used to evaluate its affinity to cytochrome c using surface plasmon resonance (SPR) technique and in the preparation of phospholipid vesicles. It may be used in the preparation of polydimethylsiloxane (PDMS) hybrid microbubbles.

Biochem/physiol Actions

Phosphatidylserine (PS) plays a key role in protein kinase C pathways. It also helps in confining the intracellular proteins to membrane leaflets of cytosol.

Packaging

20 mL Clear Glass Screw Cap Vial (840029P-500mg)
5 mL Amber Glass Screw Cap Vial (840029P-10mg)
5 mL Amber Glass Screw Cap Vial (840029P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Kanaka Hettiarachchi et al.
Journal of colloid and interface science, 344(2), 521-527 (2010-02-19)
Polymer-lipid microbubbles (PLBs) are generated by microfluidic flow-focusing devices to form a new class of long-lasting hybrid particles. The specific PLB construct developed is an elastic gas-filled microsphere with a polydimethylsiloxane (PDMS) shell containing phospholipids conjugated to functionalized polyethyleneglycol (PEG).
Carolina Varela Chavez et al.
Cellular microbiology, 17(10), 1477-1493 (2015-04-18)
Clostridium sordellii lethal toxin (TcsL) is a potent virulence factor belonging to the large clostridial glucosylating toxin family. TcsL enters target cells via receptor-mediated endocytosis and delivers the N-terminal catalytic domain (TcsL-cat) into the cytosol upon an autoproteolytic process. TcsL-cat
German Stepanov et al.
FEBS letters, 583(1), 97-100 (2008-12-09)
We attempted to evaluate the affinity of the anionic phospholipids to cytochrome c by means of surface plasmon resonance (SPR) technique and to correlate it with the cytochrome c active site alterations and peroxidase activity. Our experiments showed a strong
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