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5.04359

Palmitoylethanolamide

Name: Palmitoylethanolamide
Brand: MM

Sinónimos:

Palmitoylethanolamide, N-(2-Hydroxyethyl)hexadecanamide, PEA, Palmidrol

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Fórmula empírica (notación de Hill):

C₁₈H₃₇NO₂

Número CAS:

544-31-0

Peso molecular:

299.49

UNSPSC Code:

51111800

NACRES:

NA.77

MDL number:

MFCD00020562

Assay:

≥99% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

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Propiedades

assay

≥99% (HPLC)

Quality Segment

100

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 20 mM

storage temp.

−20°C

SMILES string

N(CCO)C(=O)CCCCCCCCCCCCCCC

InChI

1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)19-16-17-20/h20H,2-17H2,1H3,(H,19,21)

InChI key

HXYVTAGFYLMHSO-UHFFFAOYSA-N

Descripción

General description

An endogenous lipid that acts as a selective agonist for GPR55 receptors (EC₅₀ = 4, 19 800 and >30 000 nM at GPR55, CB₂ and CB₁ receptors respectively). Producing robust anti-inflammatory actions by activating PPARα (EC₅₀ = 3 µM).

Biochem/physiol Actions

Primary Target
GPR55 receptor

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Slight warming is required for complete solubilization.

Other Notes

Griffin, G., et al. 2000. J. Pharmacol. Exp. Ther.292, 886.

Lambert, D., et al. 2001. Epilepsia.42, 321.
Lambert, D., et al. 2002. Curr. Med. Chem.9, 663.
Lo Verme, J., et al. 2005. Life Sci.77, 1685.
Re, G., et al. 2005. Vet. J.173, 21.
Ryberg, R., et al. 2007. Br. J. Pharmacol.152, 1092.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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pictograms

GHS05,GHS09

signalword

Danger

pcodes

P264 - P273 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313

Hazard Classifications

Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2

Clase de almacenamiento

13 - Non Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c