8.55064
NovaSyn® TG hydroxy resin
Novabiochem®
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Servicio técnico
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Permítanos ayudarleQuality Segment
product line
NovaSyn® TG, Novabiochem®
form
beads
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename
Novabiochem®
application(s)
peptide synthesis
functional group
alcohol
storage temp.
2-30°C
General description
NovaSynTG hydroxy resin is a composite of low cross-linked polystyrene and 3000-4000 M.W. polyethylene glycol, in which the ends of the PEG chains have been functionalized with hydroxyl groups. The 130 μm beads have a narrow size distribution, high diffusion rates and excellent swelling across a wide range of solvents from toluene to water [1,2,3], making them ideally suited to the synthesis of serial and parallel libraries by organic solid phase synthesis. This support has been used for the solid phase immobilization of carboxylic acids [4,5,6,7,8,9], with cleavage by saponification with dilute aq. NaOH.
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Literature references
[1] W. Rapp, et al. in ′Innovation & Perspectives in Solid Phase Synthesis, 1st International Symposium′, R. Epton (Eds), SPCC UK Ltd., Birmingham, 1990, pp. 205.
[2] L. Zhang, et al. in ′Peptides 1990, Proc. 21st European Peptide Symposium′, E. Giralt & D. Andreu (Eds), ESCOM, Leiden, 1990, pp.196.
[3] E. Bayer (1991) Angew. Chem. Int. Ed. Engl., 30, 113.
[4] M. Hiroshige, et al. (1995) Tetrahedron Lett., 36, 4567.
[5] M. C. Fagnola, et al. (1997) Tetrahedron Lett., 38, 2307.
[6] D. Fancelli, et al. (1997) Tetrahedron Lett., 38, 2311.
[7] M. Patek, et al. (1995) Tetrahedron Lett., 36, 2227.
[8] V. Krchnak, et al. (1995) Tetrahedron Lett., 36, 6193.
[9] A. K. Szardenings & T. S. Burkoth (1997)Tetrahedron, 53, 6573.
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Literature references
[1] W. Rapp, et al. in ′Innovation & Perspectives in Solid Phase Synthesis, 1st International Symposium′, R. Epton (Eds), SPCC UK Ltd., Birmingham, 1990, pp. 205.
[2] L. Zhang, et al. in ′Peptides 1990, Proc. 21st European Peptide Symposium′, E. Giralt & D. Andreu (Eds), ESCOM, Leiden, 1990, pp.196.
[3] E. Bayer (1991) Angew. Chem. Int. Ed. Engl., 30, 113.
[4] M. Hiroshige, et al. (1995) Tetrahedron Lett., 36, 4567.
[5] M. C. Fagnola, et al. (1997) Tetrahedron Lett., 38, 2307.
[6] D. Fancelli, et al. (1997) Tetrahedron Lett., 38, 2311.
[7] M. Patek, et al. (1995) Tetrahedron Lett., 36, 2227.
[8] V. Krchnak, et al. (1995) Tetrahedron Lett., 36, 6193.
[9] A. K. Szardenings & T. S. Burkoth (1997)Tetrahedron, 53, 6573.
Analysis Note
Color (visual): white to amber to beige
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin): 0.20 - 0.30 mmol/g
Swelling Volume (in CH₂Cl₂): lot specific result
130 µm beads
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin): 0.20 - 0.30 mmol/g
Swelling Volume (in CH₂Cl₂): lot specific result
130 µm beads
Other Notes
Replaces: 01-64-0096
Legal Information
NOVASYN is a registered trademark of Merck KGaA, Darmstadt, Germany
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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