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Merck

PHR1013

Salicylic acid

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

2-Hydroxybenzoic acid

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Fórmula lineal:
2-(HO)C6H4CO2H
Número CAS:
69-72-7
Peso molecular:
138.12
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823044
EC Number:
200-712-3
Beilstein/REAXYS Number:
774890
MDL number:
MFCD00002439

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Nombre del producto

Salicylic acid, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

YGSDEFSMJLZEOE-UHFFFAOYSA-N

InChI

1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)

SMILES string

OC(=O)c1ccccc1O

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. S020000
traceable to USP 1609002

vapor density

4.8 (vs air)

vapor pressure

1 mmHg ( 114 °C)

API family

salicylic acid

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

bp

211 °C (lit.)

mp

158-161 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Application

Salicylic acid may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using spectrofluorometric technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Salicylic acid is an important material in pharmaceutical industry, obtained via the decomposition of acetylsalicylic acid. Salicylic acid is widely used in food industry for producing dyes and artificial scents. It also shows therapeutic potential in protecting the skin from sun damage and hence finds applications in cosmetics and medicine.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC3036 in the slot below. This is an example certificate only and may not be the lot that you receive.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 2

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 1

flash_point_f

314.6 °F - closed cup

flash_point_c

157 °C - closed cup

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Nickel?aluminum layered double hydroxide as a nanosorbent for selective solid-phase extraction and spectrofluorometric determination of salicylic acid in pharmaceutical and biological samples
Abdolmohammad-Zadeh H, et al.
Talanta, 84(2), 368-373 (2011)
Simultaneous determination of naproxen, salicylic acid and acetylsalicylic acid by spectrofluorimetry using partial least-squares (PLS) multivariate calibration
Navalon A, et al.
Talanta, 48(2), 469-475 (1999)
E Benfeldt et al.
Acta dermato-venereologica, 79(5), 338-342 (1999-09-24)
Our aim was to simultaneously investigate 2 techniques for in vivo sampling of peripheral compartment pharmacokinetics after systemic administration of acetylsalicylic acid. Ten volunteers were given 2 g acetylsalicylic acid orally. Blood samples and dialysates from 4 microdialysis probes inserted
Tsung-Meng Wu et al.
Plant molecular biology, 83(4-5), 379-390 (2013-06-21)
Glutathione reductases (GRs) are important components of the antioxidant machinery that plants use to respond against abiotic stresses. In rice, one cytosolic and two chloroplastic GR isoforms have been identified. In this work, we describe the cloning and characterization of
Dorothea Ellinger et al.
Plant physiology, 161(3), 1433-1444 (2013-01-22)
A common response by plants to fungal attack is deposition of callose, a (1,3)-β-glucan polymer, in the form of cell wall thickenings called papillae, at site of wall penetration. While it has been generally believed that the papillae provide a
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