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Merck

PHR1533

Colesterol

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

3β-Hidroxi-5-colesteno, 5-Colesten-3β-ol

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About This Item

Fórmula empírica (notación de Hill):
C27H46O
Número CAS:
57-88-5
Peso molecular:
386.65
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823445
EC Number:
200-353-2
Beilstein/REAXYS Number:
1915888
MDL number:
MFCD00003646

Nombre del producto

Colesterol, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

HVYWMOMLDIMFJA-DPAQBDIFSA-N

InChI

1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1

SMILES string

CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. C2155000
traceable to USP 1131960

API family

cholesterol

form

powder

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

bp

360 °C (lit.)

mp

147-149 °C (lit.)

solubility

water: soluble 0.00003 g/L at 20 °C

density

1.067 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

-10 to -25°C

Quality Level

300

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Categorías relacionadas

Biochem/physiol Actions

Componente principal de todas las membranas biológicas; ~ el 25 % de todos los lípidos cerebrales es colesterol.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Application

Cholesterol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and food products by gas chromatography, or by high performance liquid chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Cholesterol is a waxy material that belongs to the class of sterol-lipids found naturally in foods from animal sources, such as egg yolks, meat, and cheese. It serves as a precursor for the biosynthesis of steroid hormones, bile acid and vitamin D.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC0249 in the slot below. This is an example certificate only and may not be the lot that you receive.

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Chemistry
Cholesterol: Chemistry, Biochemistry, and Pathology (2015)
Cholesterol oxidation: health hazard and the role of antioxidants in prevention
Valenzuela A, et al.
Biological Research, 36(3-4), 291-302 (2003)
Simultaneous analysis of tocopherols, cholesterol, and phytosterols using gas chromatography
Du M and Ahn DU
Journal of Food Science, 67(5), 1696-1700 (2002)
An isocratic HPLC method for the simultaneous determination of cholesterol, cardiolipin, and DOPC in lyophilized lipids and liposomal formulations
Simonzadeh N
Journal of Chromatographic Science, 47(4), 304-308 (2009)
Daniel I Swerdlow et al.
Lancet (London, England), 385(9965), 351-361 (2014-09-30)
Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the intended drug target. We used single nucleotide polymorphisms in the HMGCR
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