EPS002
MS-275
A HDAC1 and HDAC3 inhibitor
Sinónimos:
MS-275 (Entinostat, SNDX-275), 3-pyridinylmethyl [[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]carbamate, N-(2-Aminophenyl)-4-[N-(pyridine-3ylmethoxycarbonyl)aminomethyl]benzamide
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Fórmula empírica (notación de Hill):
C21H20N4O3
Número CAS:
Peso molecular:
376.41
NACRES:
NA.41
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥99%
Servicio técnico
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Permítanos ayudarleassay
≥99%
solubility
DMSO: 38 mg/mL
storage temp.
−20°C
SMILES string
Nc1ccccc1NC(=O)c2ccc(CNC(=O)OCc3cccnc3)cc2
InChI
1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26)
InChI key
INVTYAOGFAGBOE-UHFFFAOYSA-N
Gene Information
General description
Preferentially inhibits HDAC1 (IC50=300 nM) over HDAC3 (IC50=8 μM). Has no inhibitory activity towards HDAC8 (IC50>100 μM).
Application
MS-275 has been used as a histone deacetylase-1 inhibitor.
Biochem/physiol Actions
HDAC inhibitor; antiproliferative.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Repr. 1A
Clase de almacenamiento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Heather MacTavish et al.
PloS one, 5(12), e14462-e14462 (2011-02-02)
Histone deacetylase inhibitors (HDI) dampen cellular innate immune response by decreasing interferon production and have been shown to increase the growth of vesicular stomatitis virus and HSV. As attenuated tumour-selective oncolytic vaccinia viruses (VV) are already undergoing clinical evaluation, the
HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis
TingDong Y et al.
Nature Communications, 100 (2018)
Marta Bombardo et al.
Scientific reports, 8(1), 9391-9391 (2018-06-22)
Adult pancreatic acinar cells have the ability to re-enter the cell cycle and proliferate upon injury or tissue loss. Despite this mitotic ability, the extent of acinar proliferation is often limited and unable to completely regenerate the injured tissue or