C1057
Butyrylcholinesterase from equine serum
lyophilized powder, ≥900 units/mg protein
Sinónimos:
Acylcholine acyl-hydrolase, Choline esterase, butyryl, Pseudocholinesterase
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Número CAS:
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
232-579-2
MDL number:
Specific activity:
≥900 units/mg protein
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lyophilized powder
Quality Level
specific activity
≥900 units/mg protein
mol wt
tetramer 440 kDa
composition
Protein, ≥10%
solubility
H2O: soluble 10 mg/mL
application(s)
diagnostic assay manufacturing
storage temp.
−20°C
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Application
Selective inhibition of BChE activity can be used in the detection of organophosphates. Its use in the treatment of organophosphate toxicity has been explored. It has been reported that the level of BChE in human blood correlates to the degree of protection against potentially toxic nerve agents. Cholinesterases have also been investigated for their role in Alzheimer′s disease.
Biochem/physiol Actions
Butyrylcholinesterase (BChE) is a serine hydrolase that is structurally similar to acetylcholinesterase (AChE), but differs in substrate specificities and inhibitor sensitivities.BChE can, unlike AChE, efficiently hydrolyze larger esters of choline such as butyrylcholine and benzoylcholine. The enzyme is a tetrameric glycoprotein with four equal subunits (110 kDa each). The enzyme is activated by Ca2+ and Mg2+. The activity is constant over the pH range of 6.0-8.0. It is inhibited by betaine, nicotine, organophosphates, and carbamate.
Physical form
Highly purified; contains buffer salts
Analysis Note
Protein determined by biuret
Other Notes
One unit will hydrolyze 1.0 μmole of butyrylcholine to choline and butyrate per min at pH 8.0 at 37 °C. The activity obtained using butyrylcholine as substrate is ~2.5 times that obtained using acetylcholine.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Jianhua Liu et al.
The Journal of clinical endocrinology and metabolism, 93(5), 1980-1987 (2008-03-20)
Ghrelin, an acylated peptide hormone secreted from the gut, regulates appetite and metabolism. Elucidating its pattern of secretion in the fed and fasted states is important in the face of the obesity epidemic. Our objective was to examine changes in
Hatice Esra Duran
Biotechnology and applied biochemistry, 70(1), 68-82 (2022-02-04)
Alzheimer's disease (AD) is a neurodegenerative disorder. The disease is characterized by dementia, memory impairment, cognitive impairment, and speech impairment. Cholinesterases (ChEs; AChE, acetylcholinesterase and BChE, butyrylcholinesterase) inhibitors and their benefits of cholinergic replacement in the treatment of AD have
Tarek Mohamed et al.
Bioorganic & medicinal chemistry letters, 20(12), 3606-3609 (2010-05-18)
A group of 2,4-disubstituted pyrimidine derivatives (7a-e, 8a-e and 9a-d) that possess a variety of C-2 aliphatic five- and six-membered heterocycloalkyl ring in conjunction with a C-4 arylalkylamino substituent were designed, synthesized and evaluated as cholinesterase (ChE) inhibitors. The steric
Keriman Ozadali-Sari et al.
Bioorganic chemistry, 72, 208-214 (2017-05-10)
The present study describes the synthesis, pharmacological evaluation (BChE/AChE inhibition, Aβ antiaggregation, and neuroprotective effects), and molecular modeling studies of novel 2-[4-(4-substitutedpiperazin-1-yl)phenyl]benzimidazole derivatives. The alkyl-substituted derivatives exhibited selective inhibition on BChE with varying efficiency. Compounds 3b and 3d were found
Yichuang Wu et al.
Frontiers in pharmacology, 13, 905708-905708 (2022-07-29)
Current studies have found that butyrylcholinesterase (BuChE) replaces the biological function of acetylcholinesterase (AChE) in the late stage of Alzheimer's disease. Species in the genus of Fallopia, rich in polyphenols with diverse chemical structures and significant biological activities, are considered
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