H5042
Cytochrome P450 3A4 human
recombinant, expressed in E. coli
Sinónimos:
Cytochrome P450, purified, soluble, 1,4-cineole 2-exo-monooxygenase, Albendazole sulfoxidase, CYP3A3, CYP3A4, Cytochrome P450 NF-25, Cytochrome P450-PCN1
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Form:
liquid
Assay:
3.5—25 mg protein/mL (Bradford)
Biological source:
human
Recombinant:
expressed in E. coli
Mol wt:
57318.7 g/mol
Servicio técnico
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Permítanos ayudarlebiological source
human
Quality Level
recombinant
expressed in E. coli
description
purified, soluble
assay
3.5—25 mg protein/mL (Bradford)
form
liquid
specific activity
12-200 units/mg protein
mol wt
57318.7 g/mol
concentration
3.5-25 mg protein/mL (protein), 50-150 nmol/mL (P450), 6-14 nmol/mg protein (specific content)
technique(s)
cell based assay: suitable
solubility
water: soluble
NCBI accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... CYP3A4(1576)
General description
Research area: IMMUNO AND CKS
Cytochrome P450 3A4 (CYP3A4) indicates a mammalian enzyme (CYP) family 3, subfamily A, gene 4. There are 57 CYP genes and 33 pseudogenes in humans, organized into 18 families and 42 subfamilies. Among these, the 3A4 isoform (CYP3A4) is the most prevalent and is primarily found in the liver and gastrointestinal tract.
Cytochrome P450 3A4 (CYP3A4) indicates a mammalian enzyme (CYP) family 3, subfamily A, gene 4. There are 57 CYP genes and 33 pseudogenes in humans, organized into 18 families and 42 subfamilies. Among these, the 3A4 isoform (CYP3A4) is the most prevalent and is primarily found in the liver and gastrointestinal tract.
Application
Cytochrome P450 3A4 human has been used in circular dichroism analysis.
Biochem/physiol Actions
Cytochrome P450 3A4 (CYP3A4) is one of the isoforms of cytochrome P450 (P450s). Cytochrome P450s (P450s) plays a vital role in processing endogenous compounds and xenobiotics, including pollutants, environmental compounds, and drug molecules. CYP3A4 oxidizes more than 90% of marketed drugs through various metabolic processes.CYP3A4 mRNA expression is upregulated in pediatric Crohn’s disease. Moreover, it provides high tolerance against herbicides such as mefenacet, amiprofos-methyl, pyributicarb, norflurazon, trifluralin, pendimethalin, chlorotoluron, and chloroacetamides.
Other Notes
One unit will convert 1.0 nanomole of testosterone to 6-beta-testosterone per minute at pH 7.4 at 37 °C.
Supplied as purified soluble proteins, rather than microsomal preparations.
Clase de almacenamiento
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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Understanding the mechanism of cytochrome P450 3A4: recent advances and remaining problems
Sevrioukova IF, et al.
Journal of Separation Science, 42(9), 3116-3126 (2013)
Understanding the mechanism of cytochrome P450 3A4: recent advances and remaining problems
Sevrioukova IF, et al.
Journal of Separation Science, 42(9), 3116-3126 (2013)
Modulation of Carbon Nanotubes' Perturbation to the Metabolic Activity of CYP3A4 in the Liver
Zhang Y, et al.
Advances in Functional Materials, 26(6), 841-850 (2016)