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L8000

L-Leucine

Name: <SC>L</SC>-Leucine
Brand: SIGMA

≥98% (HPLC), suitable for ligand binding assays

Sinónimos:

(S)-2-Amino-4-methylpentanoic acid

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Fórmula lineal:

(CH₃)₂CHCH₂CH(NH₂)CO₂H

Número CAS:

61-90-5

Peso molecular:

131.17

NACRES:

NA.26

PubChem Substance ID:

24896488

eCl@ss:

32160406

UNSPSC Code:

12352209

EC Number:

200-522-0

MDL number:

MFCD00002617

Beilstein/REAXYS Number:

1721722

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Propiedades

Nombre del producto

L-Leucine, reagent grade, ≥98% (HPLC)

grade

reagent grade

Quality Segment

200

assay

≥98% (HPLC)

form

powder

technique(s)

ligand binding assay: suitable

impurities

isoleucine and methionine, essentially free

color

white to off-white

mp

>300 °C (lit.)

application(s)

peptide synthesis

SMILES string

CC(C)C[C@H](N)C(O)=O

InChI

1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1

InChI key

ROHFNLRQFUQHCH-YFKPBYRVSA-N

Descripción

Application

L-Leucine has been used as an agonist of mechanistic target of rapamycin (mTOR) to determine whether AMPK/mTOR pathway is involved in berberine-mediated autophagy in J774A.1 cells. It has also been used for the selection of transformed cells.

Biochem/physiol Actions

Leucine is a non-glucogenic, essential amino acid. It is a branched-chain amino acid that is a structural component of proteins. Leucine positively influences insulin release to eliminate toxic sugars out of the blood. The degradation of leucine leads to the formation of ketone bodies.

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Clase de almacenamiento

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c