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O8757

Ofloxacin

Name: Ofloxacin
Brand: SIGMA

fluoroquinolone antibiotic

Sinónimos:

Dextrofloxacin

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Fórmula empírica (notación de Hill):

C₁₈H₂₀FN₃O₄

Número CAS:

82419-36-1

Peso molecular:

361.37

UNSPSC Code:

51282956

PubChem Substance ID:

24278613

NACRES:

NA.76

MDL number:

MFCD00226105

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Propiedades

biological source

synthetic

Quality Segment

200

form

powder

solubility

1 M NaOH: soluble 50 mg/mL

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycobacteria

mode of action

DNA synthesis | interferes, enzyme | inhibits

storage temp.

2-8°C

SMILES string

FC1=C(C3=[c]4[n](cc([c]([c]4=C1)=O)C(=O)O)C(CO3)C)N2CCN(CC2)C

InChI

1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)

InChI key

GSDSWSVVBLHKDQ-UHFFFAOYSA-N

Gene Information

human ... CSNK2A1(1457), KCNH1(3756)
rat ... Gabra1(29705)

Descripción

General description

Chemical structure: fluoroquinolone

Application

Ofloxacin is a synthetic fluoroquinolone with broad-spectrum antibacterial activity. It is a nalidixic acid analog. It is given to patients before undergoing retinal reattachment surgery.

Biochem/physiol Actions

Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, which haults DNA replication and cell division. Ofloxacin has been shown to convert LytA from the inactive E-form to the active C-form. It is a chiral molecule that inhibits pneumococcal cell wall-degrading virulence factors.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

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Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c