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Merck

T7941

Monoclonal Anti-β-Tubulin IV antibody produced in mouse

clone ONS.1A6, ascites fluid

Sinónimos:

Anti-DYT4, Anti-TUBB4, Anti-beta-5

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD02095891

Nombre del producto

Monoclonal Anti-β-Tubulin IV antibody produced in mouse, clone ONS.1A6, ascites fluid

antibody product type

primary antibodies

biological source

mouse

conjugate

unconjugated

antibody form

ascites fluid

clone

ONS.1A6, monoclonal

mol wt

antigen ~55 kDa

species reactivity

hamster, chicken, human, bovine, rat, mouse

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 1:400 using cultured human breast adenocarcinoma cell line MCF-7

isotype

IgG1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... TUBB4(10382)
mouse ... Tubb4(22153)
rat ... Tubb4(29213)

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunocytochemistry (1 paper)
Immunofluorescence (1 paper)
Western Blotting (1 paper)
Monoclonal Anti-β-Tubulin IV antibody has been used in immunostaining.
Monoclonal Anti-β-Tubulin IV antibody is suitable for use in immunohistochemistry (formalin-fixed, paraffin-embedded sections), indirect ELISA, microarray and western blot (1:400 using cultured human breast adenocarcinoma cell line MCF-7). The product may also be used for immunocytochemistry and immunofluorescence .

Biochem/physiol Actions

β-Tubulin IV creates the oligodendrocyte microtubule network, that helps in the transport of myelin proteins, lipids and RNA at the time of myelination. It participates in the generation of early fibrotic stages. TUBB4 plays a major role in the transport and proper localization of N-cadherin within the plasma membrane.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

β-Tubulin IV codes for β-tubulin 4A (TUBB4A). TUBB4A is expressed in the central nervous system by oligodendrocytes. It is located on human chromosome 19p13.3.
Microtubules are heterodimeric proteins that comprise of α- and β-tubulins. β-tubulins have four different isotypes in brain cells, ranging from β I to β IV . Anti-tubulin antibodies are useful to study the localization of tubulin proteins. Monoclonal Anti-β-Tubulin IV antibody is specific for epitope located in the C-terminal sequence of β-tubulin isotype IV in humans, bovines, hamsters, rats, mice and chickens. The product does not react with other tubulin isotypes.

Immunogen

synthetic peptide corresponding to the C-terminal sequence of β-tubulin isotype IV, conjugated to BSA.

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Clase de almacenamiento

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
0000471603
0000471603
0000411087
0000411087
0000395476

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beta IV tubulin is selectively expressed by oligodendrocytes in the central nervous system
Terada N, et al.
Glia, 50(3), 212-222 (2005)
Heat shock transcription factor 1 is required for maintenance of ciliary beating in mice
Takaki E, et al.
The Journal of Biological Chemistry, 282(51), 37285-37292 (2007)
The many faces of TUBB4A mutations
Lohmann K and Klein C
Neurogenetics, 15(2), 81-81 (2014)
Tubulin beta 3 and 4 are involved in the generation of early fibrotic stages
Wawro M E, et al.
Cellular Signalling, 38(3), 26-38 (2017)
Shubing Zhang et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 242(6), 678-686 (2013-03-26)
The Notch signaling pathway plays complex roles in developing lungs, including regulation of proximodistal fates, airway cell specification and differentiation. However, the specific Notch-mediated signals involved in lung development remain unclear. Here we report that Jagged1 is expressed in a
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