P9547
Prilocaine hydrochloride
≥98% (TLC)
Synonym(s):
N-(2-Methylphenyl)-2-(propylamino)propanamide hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C13H20N2O · HCl
CAS Number:
Molecular Weight:
256.77
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
217-244-0
MDL number:
InChI key
BJPJNTKRKALCPP-UHFFFAOYSA-N
InChI
1S/C13H20N2O.ClH/c1-4-9-14-11(3)13(16)15-12-8-6-5-7-10(12)2;/h5-8,11,14H,4,9H2,1-3H3,(H,15,16);1H
SMILES string
Cl[H].CCCNC(C)C(=O)Nc1ccccc1C
assay
≥98% (TLC)
form
powder
originator
AstraZeneca
Quality Level
Gene Information
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Related Categories
Biochem/physiol Actions
Used for local nerve block and for spinal anesthesia; pharmacological properties are similar to those of lidocaine.
Features and Benefits
This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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K Nakamura et al.
Canadian journal of anaesthesia = Journal canadien d'anesthesie, 46(5 Pt 1), 476-482 (1999-06-01)
To determine whether prilocaine, a local anesthetic, induces apoptosis in osteoblastic cells. After reaching subconfluence, human osteoblastic Saos-2 and MG63 cells and mouse osteoblastic MC3T3-E1 cells were exposed for 48 hr to varying concentrations of prilocaine up to 10 mM
Young-Eun Moon et al.
Archives of physical medicine and rehabilitation, 94(5), 919-924 (2012-12-25)
To compare the effects of a vapocoolant spray and an eutectic mixture of local anesthetics (EMLA) cream in reducing pain during needle electromyography examination. Randomized controlled trial. Physical medicine and rehabilitation department of a university hospital. Adults who underwent needle
S Schreiber et al.
European journal of pediatrics, 172(2), 265-268 (2012-10-25)
Venipuncture and intravenous cannulation are the most common painful procedures performed on children. The most widely used topical anesthetic is eutectic mixture of local anesthetics (EMLA). EMLA use is associated with a transient cutaneous vasoconstriction which can make it difficult
Michelle Briggs et al.
The Cochrane database of systematic reviews, 11, CD001177-CD001177 (2012-11-16)
Venous leg ulcers affect up to 1% of people at some time in their lives and are often painful. The main treatments are compression bandages and dressings. Topical treatments to reduce pain during and between dressing changes are sometimes used.
Matthew A Petoe et al.
Journal of neurophysiology, 109(4), 1091-1096 (2012-12-12)
Temporary deafferentation of the upper limb, with ischemic or anesthetic nerve block, has rapid effects on sensorimotor cortex. Cutaneous anesthesia of the forearm has recently been found to improve sensory and motor function of the paretic hand in chronic stroke
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