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Merck

D5431

Diethylamine NONOate diethylammonium salt

≥98%

Synonym(s):

DEA NONOate, DEA/NO diethylammonium salt

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About This Item

Linear Formula:
(CH3CH2)2N–N(N=O)O- (CH3CH2)2NH2+
CAS Number:
372965-00-9
Molecular Weight:
206.29
NACRES:
NA.22
PubChem Substance ID:
329798805
UNSPSC Code:
12352116
MDL number:
MFCD00216152
Assay:
≥98%
Form:
solid

Key Documents

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Product Name

Diethylamine NONOate diethylammonium salt, ≥98%

InChI

1S/C4H11N3O2.C4H11N/c1-3-6(4-2)7(9)5-8;1-3-5-4-2/h9H,3-4H2,1-2H3;5H,3-4H2,1-2H3

SMILES string

CCNCC.CCN(CC)N(O)N=O

InChI key

LBJLVZKEUWCGIA-UHFFFAOYSA-N

description

t1/2 16 min phosphate buffer, 22 °C NO release

assay

≥98%

form

solid

shipped in

dry ice

storage temp.

−70°C

Application

DEA/NO diethylammonium salt can be used as:        
  • A nitric oxide (NO) donor.
  • A reagent for reductive nitrosylation of Wilkinson′s catalyst.

Used as:
  • Reagent for reductive nitrosylation of Wilkinson′s catalyst
  • Nitric oxide (NO) donor

Biochem/physiol Actions

NO donor

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SLCK9803
SLCH3638
SLCD6671
SLCB8130
SLBS2808V

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Xin Zhang et al.
The Journal of biological chemistry, 277(50), 48472-48478 (2002-10-09)
4,5-Diaminofluorescein (DAF-2) is widely used for detection and imaging of NO based on its sensitivity, noncytotoxicity, and specificity. In the presence of oxygen, NO and NO-related reactive nitrogen species nitrosate 4,5-diaminofluorescein to yield the highly fluorescent DAF-2 triazole (DAF-2T). However
Xi Ye et al.
The Journal of physiology, 596(16), 3553-3566 (2018-06-05)
Prolonged exposure to vascular endothelial growth factor A (VEGF-A) inhibits agonist-mediated endothelial cell Ca2+ release and subsequent activation of intermediate conductance Ca2+ -activated K+ (IKCa ) channels, which underpins vasodilatation as a result of endothelium-dependent hyperpolarization (EDH) in mouse resistance
Joseph C Galley et al.
Molecular pharmacology, 95(6), 629-637 (2019-04-17)
Nitric oxide (NO) stimulates soluble guanylyl cyclase (sGC) activity, leading to elevated intracellular cyclic guanosine 3',5'-monophosphate (cGMP) and subsequent vascular smooth muscle relaxation. It is known that downregulation of sGC expression attenuates vascular dilation and contributes to the pathogenesis of
Yi Shi et al.
PloS one, 9(9), e107787-e107787 (2014-09-24)
The aging gene p66Shc, is an important mediator of oxidative stress-induced vascular dysfunction and disease. In cultured human aortic endothelial cells (HAEC), p66Shc deletion increases endothelial nitric oxide synthase (eNOS) expression and nitric oxide (NO) bioavailability via protein kinase B.
Rodolfo Urbano et al.
Cell host & microbe, 23(5), 594-606 (2018-05-01)
Staphylococcus aureus is a commensal bacterium that can asymptomatically colonize its host but also causes invasive infections. Quorum sensing regulates S. aureus virulence and the transition from a commensal to a pathogenic organism. However, little is known about how host innate
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