MAB1973Z

Anti-Integrin α1 Antibody, clone FB12, azide free

Name: Anti-Integrin α1 Antibody, clone FB12, azide free
Brand: MM

clone FB12, Chemicon^®, from mouse

Synonym(s):

CD49a, MAB1973

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Product Name

Anti-Integrin α1 Antibody, clone FB12, azide free, clone FB12, Chemicon^®, from mouse

Quality Level

100

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

FB12, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon^®

technique(s)

ELISA: suitable
flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

NM_181501.1

UniProt accession no.

P56199

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... ITGA1(3672)

Related Categories

Flow Cytometry Antibodies

Protein Biology

Analysis Note

Control
Microvascular endothelium

Application

Detect Integrin α1 using this Anti-Integrin α1 Antibody, clone FB12, azide free validated for use in ELISA, FC, IH, IP, FUNC & WB.

Immunohistochemistry: 2 μg/mL, with paraformaldehyde fixation. Immunoblotting: 2 μg/mL

Immunoprecipitation: 1 μg/mL

FACS analysis: 2 μg/mL

ELISA: 0.5 μg/mL

Inhibition of activated human lymphocyte binding to laminin, collagen IV and fibronectin (Fabbri, 1996): 1-5 μg/mL

Optimal working dilutions must be determined by end user.

Biochem/physiol Actions

Reacts with the I domain (Val151 - Ala364) of human alpha1 integrin (Fabbri, 1996). Precipitates proteins of Mr 180 kDa, pI 5.9-6.0 (alpha chain) and Mr 115 kDa, pI 4.5-5.0 (beta chain) from human lymphocyte lysates (Zocchi, 1991). Does not recognize recombinant I domain of rat integrin alpha1.

General description

130 kDa

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Format: Purified

Purified immunoglobulin in 0.02M PB, pH 7.6, 0.25M NaCl.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Chondroitin Sulfate Promotes the Proliferation of Keloid Fibroblasts Through Activation of the Integrin and Protein Kinase B Pathways.

Yasuhiro Katayama et al.

International journal of molecular sciences, 21(6) (2020-03-19)

Keloids are dermal fibroproliferative tumors that arise beyond the boundary of the original wound edges and invades adjacent tissue. Keloids are characterized by the extensive production of extracellular matrix (ECM) and abnormal fibroblast proliferation. Chondroitin sulfate (CS) is one of

Recombinant collagen scaffolds as substrates for human neural stem/progenitor cells.

Richard A Que et al.

Journal of biomedical materials research. Part A, 106(5), 1363-1372 (2018-01-18)

Adhesion to the microenvironment profoundly affects stem cell functions, including proliferation and differentiation, and understanding the interaction of stem cells with the microenvironment is important for controlling their behavior. In this study, we investigated the effects of the integrin binding

Integrin ?5?1 facilitates cancer cell invasion through enhanced contractile forces.

Mierke, CT; Frey, B; Fellner, M; Herrmann, M; Fabry, B

Journal of Cell Science null

Angiogenesis in collagen I requires alpha2beta1 ligation of a GFP*GER sequence and possibly p38 MAPK activation and focal adhesion disassembly.

Shawn M Sweeney et al.

The Journal of biological chemistry, 278(33), 30516-30524 (2003-06-06)

Angiogenesis depends on proper collagen biosynthesis and cross-linking, and type I collagen is an ideal angiogenic scaffold, although its mechanism is unknown. We examined angiogenesis using an assay wherein confluent monolayers of human umbilical vein endothelial cells were overlain with

Mapping heterogeneity in patient-derived melanoma cultures by single-cell RNA-seq.

Tobias Gerber et al.

Oncotarget, 8(1), 846-862 (2016-12-03)

Recent technological advances in single-cell genomics make it possible to analyze cellular heterogeneity of tumor samples. Here, we applied single-cell RNA-seq to measure the transcriptomes of 307 single cells cultured from three biopsies of three different patients with a BRAF/NRAS

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Global Trade Item Number

SKU	GTIN
MAB1973Z	04053252610981

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