Aphidicolin from Nigrospora sphaerica

Product Name

Aphidicolin from Nigrospora sphaerica, ≥98% (HPLC), powder

InChI

1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1

SMILES string

[H][C@@]12CC[C@@]3([H])[C@](C)(CO)[C@H](O)CC[C@]3(C)[C@]14CC[C@](O)(CO)[C@]([H])(C2)C4

InChI key

NOFOAYPPHIUXJR-APNQCZIXSA-N

assay

≥98% (HPLC)

form

powder

optical activity

[α]27/D +12°, c = 1 in methanol(lit.)

color

white

mp

227-233 °C (lit.)

solubility

ethanol: 1 mg/mL (stable at least a week at 4°C.)
DMSO: 10 mg/mL (stable at least six weeks at −20°C.)
methanol: 10 mg/mL
H₂O: insoluble

antibiotic activity spectrum

neoplastics
viruses

mode of action

DNA synthesis | interferes

storage temp.

2-8°C

Quality Level

300

Gene Information

human ... POLA1(5422), POLD1(5424), POLG(5428)