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H2775

DL-threo-β-Hydroxyaspartic acid

Name: <SC>DL</SC>-<I>threo</I>-β-Hydroxyaspartic acid
Brand: SIGMA

Synonym(s):

threo-2-Amino-3-hydroxysuccinic acid

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About This Item

Empirical Formula (Hill Notation):

C₄H₇NO₅

CAS Number:

4294-45-5

Molecular Weight:

149.10

PubChem Substance ID:

24278465

eCl@ss:

32160406

UNSPSC Code:

12352106

NACRES:

NA.32

EC Number:

224-299-4

MDL number:

MFCD00036749

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Properties

Quality Level

200

storage temp.

−20°C

SMILES string

N[C@H]([C@@H](O)C(O)=O)C(O)=O

InChI

1S/C4H7NO5/c5-1(3(7)8)2(6)4(9)10/h1-2,6H,5H2,(H,7,8)(H,9,10)/t1-,2-/m1/s1

InChI key

YYLQUHNPNCGKJQ-JCYAYHJZSA-N

Gene Information

human ... GLUL(2752)
mouse ... GLUL(14645)

Description

General description

DL-threo-β-hydroxyaspartic acid (THA) is a glutamate uptake inhibitor.

Application

DL-threo-β-Hydroxyaspartic acid (THA) has been used to block glutamate transport in cannulated sprague dawley rat.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Iron is a potential key mediator of glutamate excitotoxicity in spinal cord motor neurons.

Jixu Yu et al.

Brain research, 1257, 102-107 (2009-01-13)

Threohydroxyaspartate (THA)-induced glutamate excitotoxicity in organotypic culture of rat spinal cord is a well-known model of motor neuron degeneration. THA causes accumulation of synaptic glutamate and over stimulation of the postsynaptic receptor by inhibiting glutamate uptake. This model has also

Glutamate transporters of blood platelets as potential peripheral markers to analyze changes of glutamate transport activity in brain under altered gravity conditions.

Tatiana Borisova et al.

Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology, 14(1), P81-P82 (2008-04-01)

Activity of high-affinity glutamate transporters was altered in brain nerve terminals under artificial gravity conditions. Blood platelets contain glutamate transporters and are able to uptake glutamate. The goal of the research was to analyze comparatively L-[14C]glutamate transport in neuronal and

Huperzine A provides neuroprotection against several cell death inducers using in vitro model systems of motor neuron cell death.

Richelle A Hemendinger et al.

Neurotoxicity research, 13(1), 49-61 (2008-03-28)

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease resulting from the progressive loss of motor neurons in the spinal cord and brain. To date, clinically effective neuroprotective agents have not been available. The current study demonstrates for the first time

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