M0880
Ethyl methanesulfonate
liquid
Synonym(s):
Ethyl mesylate, Methanesulfonic acid ethyl ester
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About This Item
Linear Formula:
CH3SO3CH2CH3
CAS Number:
Molecular Weight:
124.16
UNSPSC Code:
12352108
NACRES:
NA.25
PubChem Substance ID:
EC Number:
200-536-7
Beilstein/REAXYS Number:
773969
MDL number:
Form:
liquid
Quality level:
form
liquid
Quality Level
refractive index
n20/D 1.418 (lit.)
bp
85-86 °C/10 mmHg (lit.)
density
1.206 g/mL at 20 °C
SMILES string
CCOS(C)(=O)=O
InChI
1S/C3H8O3S/c1-3-6-7(2,4)5/h3H2,1-2H3
InChI key
PLUBXMRUUVWRLT-UHFFFAOYSA-N
Application
Ethyl methanesulfonate had been used for inducing mutation in mouse embryonic fibroblasts, yeast human embryonic kidney cell lines and human lymphocytes.
Biochem/physiol Actions
Ethyl methanesulfonate is a DNA ethylating agent, mutagenic to plants and animals and carcinogenic in mammals. It has been used as a model alkylating agent in studies of DNA repair processes. EMS induces base substitutions of guanine-cytosine (G/C) to adenine-thymine (A/T). EMS also generates point mutations and single nucleotide polymorphisms in genomes. EMS is potential chemical mutagen used for inducing mutation in rice, wheat and Arabidopsis thaliana.
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Danger
Hazard Classifications
Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Repr. 2 - Skin Irrit. 2 - Skin Sens. 1
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
212.0 °F
flash_point_c
100 °C
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
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