N8912

Monoclonal Anti-NG2 antibody produced in mouse

Name: Monoclonal Anti-NG2 antibody produced in mouse
Brand: SIGMA

clone 132.38, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-Chondroitin Sulfate Proteoglycan Melanoma-associated, Anti-MCSP, Anti-MCSPG, Anti-MEL-CSPG MSK16 Chondroitin Sulfate Proteoglycan NG2

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD08705593

Product Name

Monoclonal Anti-NG2 antibody produced in mouse, clone 132.38, purified immunoglobulin, buffered aqueous solution

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

132.38, monoclonal

form

buffered aqueous solution

species reactivity

rat

technique(s)

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 1 μg/mL using rat brain neonatal extract

UniProt accession no.

Q00657

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

rat ... Cspg4(81651)

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Western Blotting

Biochem/physiol Actions

Chondroitin sulfate proteoglycan 4 (CSPG4) or nerve/glial antigen 2 (NG2) stimulates the activation of integrins in dorsal root ganglion neurons. It also has a role in stimulating inflammatory cytokine expression in microglia.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Chondroitin sulfate proteoglycan 4 (CSPG4) or nerve/glial antigen 2 (NG2) is a growth-inhibitory chondroitin sulfate proteoglycan (CSPG) produced after spinal cord injury. It has a single glycosaminoglycan (GAG) chain. The protein belongs to the transmembrane chondroitin sulfate proteoglycans family.

Immunogen

cell extract of HEK293 cells expressing the D3 domain of rat NG2.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Entrapment via Synaptic-Like Connections between NG2 Proteoglycan+ Cells and Dystrophic Axons in the Lesion Plays a Role in Regeneration Failure after Spinal Cord Injury

Angela R

The Journal of Neuroscience (2014)

NG2, a member of chondroitin sulfate proteoglycans family mediates the inflammatory response of activated microglia.

Gao Q, ey .al

Neuroscience and Behavioral Physiology (2010)

Genetically Engineered Artificial Microvesicles Carrying Nerve Growth Factor Restrains the Progression of Autoimmune Encephalomyelitis in an Experimental Mouse Model.

Alatrash, et al.

International Journal of Molecular Sciences, 24 (2023)

Novel cell-free strategy for therapeutic angiogenesis: in vitro generated conditioned medium can replace progenitor cell transplantation.

Stefano Di Santo et al.

PloS one, 4(5), e5643-e5643 (2009-05-30)

Current evidence suggests that endothelial progenitor cells (EPC) contribute to ischemic tissue repair by both secretion of paracrine factors and incorporation into developing vessels. We tested the hypothesis that cell-free administration of paracrine factors secreted by cultured EPC may achieve

Antibody-based proteomics for esophageal cancer: Identification of proteins in the nuclear factor-?B pathway and mitotic checkpoint

Norihisa U

Cancer Science (2009)

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