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Merck

P4153

Prednisolone 21-hemisuccinate sodium salt

≥90%, powder

Synonym(s):

Δ1-Hydrocortisone 21-hemisuccinate, 1,4-Pregnadiene-11β,17,21-triol-3,20-dione 21-hemisuccinate, 11β,17α,21-Trihydroxy-1,4-pregnadiene-3,20-dione 21-hemisuccinate

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About This Item

Linear Formula:
C25H31O8Na
CAS Number:
1715-33-9
Molecular Weight:
482.50
NACRES:
NA.77
PubChem Substance ID:
24898507
UNSPSC Code:
51111800
EC Number:
216-995-1
MDL number:
MFCD00070045
Assay:
≥90%
Form:
powder
Quality level:
200

Key Documents

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biological source

synthetic

Quality Level

200

sterility

non-sterile

assay

≥90%

form

powder

color

, White to Light Yellow to Light Beige

solubility

hot water: 50 mg/mL, clear to very slightly hazy (Colorless to Light Yellow to Light Brown-Yellow)

shipped in

ambient

storage temp.

−20°C

SMILES string

[Na].[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)COC(=O)CCC(O)=O

InChI

1S/C25H32O8.Na.H/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30;;/h7,9,11,16-18,22,27,32H,3-6,8,10,12-13H2,1-2H3,(H,29,30);;/t16-,17-,18-,22+,23-,24-,25-;;/m0../s1

InChI key

HLHQSPQPHMOTMP-FKIWUUNWSA-N

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360D

Hazard Classifications

Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM7070
BCBW2082
BCBB6186V
BCBB6186
077K1581

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Ellen C La Heij et al.
American journal of ophthalmology, 143(1), 176-178 (2006-12-26)
To evaluate the six-month results of patients treated with intravitreal prednisolone sodium succinate injections for persistent diabetic macular edema. Retrospective, noncontrolled, clinical case series. Nineteen eyes had intravitreal injections with prednisolone sodium succinate. Need for retreatment was based on fluorescein
Tomofumi Ogoshi et al.
Modern rheumatology, 18(6), 552-561 (2008-07-24)
The influence of glucocorticoid (GC) on bone in rats at different ages was investigated in order to provide insight into human glucocorticoid induced osteoporosis (GCOP). Three-, 6-, and 12-month-old female Wistar rats were divided into four groups: Zero-time control (ZT)
Kouji Higashi et al.
Circulation journal : official journal of the Japanese Circulation Society, 71(7), 1052-1059 (2007-06-26)
The inflammatory mediators play an important role in the progression of coronary vasculitis in Kawasaki disease (KD), but effects of KD serum including inflammatory mediators on endothelial cells remain unknown. We hypothesized that serum activity to stimulate in vitro human
E Mabuchi et al.
The British journal of dermatology, 157(3), 596-598 (2007-06-29)
Non-Herlitz junctional epidermolysis bullosa (JEB-nH), a nonlethal variant of junctional epidermolysis bullosa (JEB), is an autosomal recessive disorder characterized by separation of the dermal-epidermal junction. JEB-nH is caused by mutations in several genes and lack of the COL17A1 gene product
Toru Ohashi et al.
Acta oto-laryngologica, 132(2), 133-140 (2011-12-29)
Abnormal action potential (AP) recovery from adaptation was manifested as increased recovery (iR) or decreased recovery (dR) relative to the normal recovery range. dR was not analyzed statistically due to the very small number of cases. iR is considered an
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