MTOX1301
Canine MDR1 Knockout MDCKII Control Cells
canine kidney (cocker spaniel)
Synonym(s):
MDCKII MDR1 KO
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About This Item
UNSPSC Code:
12352207
NACRES:
NA.24
Biological source:
canine kidney (cocker spaniel)
Product Name
Canine MDR1 Knockout MDCKII Control Cells,
biological source
canine kidney (cocker spaniel)
Quality Segment
form
liquid
storage temp.
−196°C
Application
See technical bulletin for detailed protocols
Features and Benefits
MDCK II - Madin-Darby canine kidney- is a subclone derived from the heterogenous parent line - MDCK (ECACC catalogue no. 85011435) MDCK II cells, which predominate in later passages from MDCK, are reported to display electrical resistance of 100 ohm/cm2. This strain is thought to be derived from the distal tubule or collecting duct of the nephron. The cell line can be used as an experimental model to study the generation and maintenance of cell surface polarity in epithelial cells.
The canine MDR1 (cP-gp) efflux transporter gene has been effectively disrupted in both alleles. There is no expression of the cP-gp. Validation studies have shown no efflux of standard cP-gp substrates.
Analysis Note
Tested for Mycoplasma, sterility, post-freeze viability, short terminal repeat (STR) analysis for cell line identification.
Legal Information
Exhibit 1: ADME/Tox cell lines licenseMDCKII subclone was originally isolated by Daniel Louvard, Institut Curie, Paris France.
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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