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A6981

Acamprosate calcium

≥98% (HPLC), powder

Synonym(s):

3-(Acetylamino)-1-propanesulfonic acid calcium salt (2:1)

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About This Item

Empirical Formula (Hill Notation):
C5H10Ca0.5NO4S
CAS Number:
77337-73-6
Molecular Weight:
200.24
MDL number:
MFCD00886588
UNSPSC Code:
12352200
PubChem Substance ID:
329770909
EC Number:
278-665-3
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
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Quality Level

100

assay

≥98% (HPLC)

form

powder

solubility

H2O: >5 mg/mL

storage temp.

room temp

SMILES string

CC(=O)NCCCS(=O)(=O)O[Ca]OS(=O)(=O)CCCNC(C)=O

InChI

1S/2C5H11NO4S.Ca/c2*1-5(7)6-3-2-4-11(8,9)10;/h2*2-4H2,1H3,(H,6,7)(H,8,9,10);/q;;+2/p-2

InChI key

BUVGWDNTAWHSKI-UHFFFAOYSA-L

Gene Information

human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), GABRD(2563), GABRE(2564), GABRG1(2565), GABRG2(2566), GABRG3(2567), GABRP(2568), GABRQ(55879), GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRIN3A(116443), GRIN3B(116444)

Biochem/physiol Actions

Acamprosate calcium is a GABA γ-aminobutyric acid agonist.
Acamprosate calcium is a synthetic analog of γ-aminobutyric acid (GABA) and a GABAB receptor agonist. Acamprosate calcium has been used in alcohol dependence treatments and may be an effective augmentation therapy anxiety patients.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000421018
0000421018
0000362261
0000362261
052M4709V

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Open-label trial of acamprosate as a treatment for anxiety.
Marc Hertzman et al.
Primary care companion to the Journal of clinical psychiatry, 11(5), 267-267 (2009-12-04)
Alcohol dependence treatments: comprehensive healthcare costs, utilization outcomes, and pharmacotherapy persistence
Baser, O., et al.
The American Journal of Managed Care, 8, S222-S234 (2011)
M I Wilde et al.
Drugs, 53(6), 1038-1053 (1997-06-01)
Acamprosate (calcium acetylhomotaurinate), a synthetic compound with a similar chemical structure to that of gamma-aminobutyric acid, is thought to act via several mechanisms affecting multiple neurotransmitter systems; inhibition of neuronal hyperexcitability by antagonism of excitatory amino acid activity and reduction
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