D7441
Daltroban
>98% (HPLC)
Synonym(s):
4-[2-[(4-Chlorophenylsulfonyl)amino]ethyl]benzeneacetic acid, BM-13505, SKF-96148
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About This Item
Empirical Formula (Hill Notation):
C16H16ClNO4S
CAS Number:
Molecular Weight:
353.82
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
>98% (HPLC)
form
solid
color
white
mp
132.5-137.4 °C (lit.)
solubility
DMSO: soluble 22 mg/mL
SMILES string
OC(=O)Cc1ccc(CCNS(=O)(=O)c2ccc(Cl)cc2)cc1
InChI
1S/C16H16ClNO4S/c17-14-5-7-15(8-6-14)23(21,22)18-10-9-12-1-3-13(4-2-12)11-16(19)20/h1-8,18H,9-11H2,(H,19,20)
InChI key
IULOBWFWYDMECP-UHFFFAOYSA-N
Gene Information
human ... TBXA2R(6915)
General description
Exerts protective effects on brain infarction, heart cell injury due to hypoxia and hypoglycemia and lowers serum CPK activity.
Biochem/physiol Actions
Selective thromboxane A2 receptor antagonist
Features and Benefits
This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Related Content
Zhi-Dong Ge et al.
Journal of cardiovascular pharmacology, 41(3), 481-488 (2003-02-27)
The purpose of the current study was to compare the efficacy of two structurally unrelated thromboxane A (TXA ) receptor antagonists, KT2-962 and daltroban (BM 13.505), in a dog model of myocardial ischemia/reperfusion injury. Pentobarbital-anesthetized dogs were subjected to left
Sabine Pestel et al.
Laboratory investigation; a journal of technical methods and pathology, 83(12), 1733-1741 (2003-12-24)
Various inflammatory stimuli such as anaphylatoxin C5a, zymosan, and lipopolysaccharides (LPSs) have been reported both to enhance glucose output in the perfused rat liver and to induce prostanoid (ie, prostaglandin and thromboxane) release from Kupffer cells, the resident liver macrophages.
A Rizzo et al.
The American journal of physiology, 268(5 Pt 2), H1954-H1958 (1995-05-01)
The effects of platelet-activating factor (PAF) on vascular resistance and capillary permeability were studied in the isolated rat hindquarter. Six groups were studied (n = 30): control; PAF alone (1.4 microM); and PAF (1.4 microM) pretreated with ibuprofen (30 mg/kg)