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M0319

MRS 2578

≥95% (HPLC)

Synonym(s):

1,4-Di[3-(3-isothiocyanatophenyl)thioureido]butane

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About This Item

Empirical Formula (Hill Notation):
C20H20N6S4
CAS Number:
711019-86-2
Molecular Weight:
472.67
NACRES:
NA.77
PubChem Substance ID:
24724530
UNSPSC Code:
12352200
MDL number:
MFCD07370141
Assay:
≥95% (HPLC)
Form:
powder
Storage condition:
desiccated
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assay

≥95% (HPLC)

form

powder

storage condition

desiccated

color

white

solubility

DMSO: >5 mg/mL, H2O: insoluble

storage temp.

2-8°C

SMILES string

S=C=Nc1cccc(NC(=S)NCCCCNC(=S)Nc2cccc(c2)N=C=S)c1

InChI

1S/C20H20N6S4/c27-13-23-15-5-3-7-17(11-15)25-19(29)21-9-1-2-10-22-20(30)26-18-8-4-6-16(12-18)24-14-28/h3-8,11-12H,1-2,9-10H2,(H2,21,25,29)(H2,22,26,30)

InChI key

QOHNRGHTJPFMSL-UHFFFAOYSA-N

Application

MRS 2578 has been used an antagonist of purinoceptor P2Y6:
  • to study the role of purinergic receptor in Up4A-induced relaxation in coronary small arteries from swine
  • in P. aeruginosa infected mice to test its effect on the inflammatory responses
  • to test its inhibition on neutrophil extracellular traps and monosodium urate (MSU) crystals formation in polymorphonuclear leukocytes

Biochem/physiol Actions

MRS 2578 elicits cytoprotective functionality in neuroblastoma cells and prevents dopaminergic neuron death under in vitro and in vivo conditions. It also protects microglia by delaying lipopolysaccharide-induced death.
Potent and irreversible antagonist of P2Y6 nucleotide receptor.

Features and Benefits

This compound is featured on the P2 Receptors: P2Y G-Protein Family page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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