M4910
1-Methylhistamine dihydrochloride
≥98% (TLC), powder
Synonym(s):
1-Methyl-4-(β-aminoethyl)imidazole dihydrochloride
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C6H11N3 · 2HCl
CAS Number:
Molecular Weight:
198.09
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.32
MDL number:
Product Name
1-Methylhistamine dihydrochloride, ≥98% (TLC), powder
Quality Level
assay
≥98% (TLC)
form
powder
solubility
water: 49.00-51.00 mg/mL, clear, colorless to faintly yellow
storage temp.
2-8°C
SMILES string
Cl[H].Cl[H].Cn1cnc(CCN)c1
InChI
1S/C6H11N3.2ClH/c1-9-4-6(2-3-7)8-5-9;;/h4-5H,2-3,7H2,1H3;2*1H
InChI key
AGXVEALMQHTMSW-UHFFFAOYSA-N
Gene Information
human ... HRH1(3269), HRH2(3274), HRH3(11255), HRH4(59340)
Application
1-Methylhistamine dihydrochloride has been used as a standard in the evaluation of histamine levels in aqueous humor of glaucoma patients by liquid chromatography. It has also been used as a substrate to determine amine oxidase activity.
Biochem/physiol Actions
1-Methylhistamine is present in the brain and is a metabolite of histamine that is metabolized by histamine N-methyltransferase. It acts as a biomarker for histaminergic system activity in the cerebrospinal fluid of patients suffering from Alzheimer′s disease (AD), hypersomnia, and other neurological conditions.
Major metabolite of histamine by histamine N-methyltransferase.
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Y Hashimoto et al.
Acta anaesthesiologica Scandinavica, 42(7), 858-863 (1998-08-12)
Histamine is most densely distributed in the hypothalamus and has an important effect on consciousness or wakefulness. It has been little considered whether general anesthetics could exert their effects on hypothalamic histamine metabolism. The present study was conducted to investigate
A Burban et al.
The Journal of pharmacology and experimental therapeutics, 332(3), 912-921 (2009-12-17)
Histamine potentiates activation of native and recombinant N-methyl-d-aspartate receptors (NMDARs), but its mechanisms of action and physiological functions in the brain remain controversial. Using four different models, we have further investigated the histamine-induced potentiation of various NMDAR-mediated responses. In single
Standardised evaluation of urinary excretion of N-tele-methylhistamine in different periods of age in a healthy population.
S Winterkamp et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 52 Suppl 1, S57-S58 (2003-05-21)