SML1379
Seratrodast
≥98% (HPLC)
Synonym(s):
(±)-7-(3,5,6-Trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic acid, AA-2414
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About This Item
Empirical Formula (Hill Notation):
C22H26O4
CAS Number:
Molecular Weight:
354.44
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 25 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(C(C)=C1C)C(C)=C(C(CCCCCC(O)=O)C2=CC=CC=C2)C1=O
InChI
1S/C22H26O4/c1-14-15(2)22(26)20(16(3)21(14)25)18(17-10-6-4-7-11-17)12-8-5-9-13-19(23)24/h4,6-7,10-11,18H,5,8-9,12-13H2,1-3H3,(H,23,24)
InChI key
ZBVKEHDGYSLCCC-UHFFFAOYSA-N
Gene Information
human ... TBXA2R(6915)
Biochem/physiol Actions
Seratrodast is a thromboxane A2 (TXA2) receptor (TP receptor) antagonist with anti-asthmatic activity.
Seratrodast is a thromboxane A2 (TXA2) receptor (TP receptor) antagonist with anti-asthmatic activity. Seratrodast inhibits the bronchconstriction induced by leukotriene D4 (LTD4), and platelet activating factor (PAF) with a long duration of action.
signalword
Warning
hcodes
Hazard Classifications
Repr. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Margarita Rosa Romero-Imbachi et al.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 240, 108939-108939 (2020-11-10)
Centruroides margaritatus scorpion stings are common in Colombia. However, the cardiovascular toxicity of the venom has not been clarified. To study the effect and mechanisms of action of the complete venom of C. margaritatus (CmV) on the murine cardiovascular system.