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Merck

79838

Nicotinic acid

certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Synonym(s):

3-Picolinic acid, Niacin, Pellagra preventive factor, Pyridine-3-carboxylic acid, Vitamin B3

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About This Item

Empirical Formula (Hill Notation):
C6H5NO2
CAS Number:
59-67-6
Molecular Weight:
123.11
UNSPSC Code:
12352106
NACRES:
NA.24
PubChem Substance ID:
329768645
MDL number:
MFCD00006391
Beilstein/REAXYS Number:
109591

Key Documents

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InChI

1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)

SMILES string

OC(=O)c1cccnc1

InChI key

PVNIIMVLHYAWGP-UHFFFAOYSA-N

grade

certified reference material, TraceCERT®

product line

TraceCERT®

form

powder

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

technique(s)

gas chromatography (GC): suitable

color

white

mp

236-239 °C (lit.)

application(s)

vitamins, nutraceuticals, and natural products

format

neat

Quality Level

300

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General description

Nicotinic acid is a water soluble B complex vitamin, with effective plasma lipid-lowering effect and hence is clinically used to treat hyperlipidemia.
This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO 17034. This CRM is traceable to primary material from an NMI, e.g. NIST or NMIJ.
Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate.
Download your certificate at: http://www.sigma-aldrich.com.

Application

Nicotinic acid may be used as a certified reference material for the quantification of the analyte in tablet dosage forms using reversed-phase high-performance liquid chromatography technique.

Legal Information

TraceCERT is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

flash_point_f

379.4 °F - closed cup

flash_point_c

193 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Molecular identification of nicotinic acid receptor
Soga T, et al.
Biochemical and biophysical research communications, 303(1), 364-369 (2003)
RP-HPLC method for the determination of atorvastatin calcium and nicotinic acid in combined tablet dosage form
Shah DA, et al.
Indian Journal of Pharmaceutical Sciences, 69(5), 700-700 (2007)
Sorin Tunaru et al.
Nature medicine, 9(3), 352-355 (2003-02-04)
Nicotinic acid (niacin), a vitamin of the B complex, has been used for almost 50 years as a lipid-lowering drug. The pharmacological effect of nicotinic acid requires doses that are much higher than those provided by a normal diet. Its

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